摘要
目的探讨尿微量白蛋白测定在糖尿病肾病中的诊断作用。方法用免疫散射比浊法测定 １１０例 ２型糖尿病患者和８０例健康人的尿微量白蛋白、尿ｌｇＧ、尿转铁蛋白、尿α１─微球蛋白。所有患者的尿常规检查尿蛋白阴性、肾功能正常。结果尿微量白蛋白在糖尿病患者明显升高（ｐ＜０．００１），随着病程延长，升高愈加明显。病程超过 １０年，尿ｌｇＧ、尿转铁蛋白、尿α１─微球蛋白也升高（ｐ＜ ０． ００１），糖尿病合并高血压者尿微量蛋白升高更明显（ｐ＜ ０．００１）。结论尿微量白蛋白测定对糖尿病肾病变最敏感，合并高血压可加重肾损害。
Objective To explore the clinical value of urine microalbuminuria in the diagnosis of diabetic nephropathy in patients with type - 2 diabetes mellitus. Methods By using RIA, measurements were made on the urine microalbuminuria, IgG and α1 -mi- croglobulin in 110 cases with type - 2 diabetes mellitus and 80 healthy cases of control group. All the cases had the normal renal functions and revealed no urine protein in routine test. Results The level of urine microalbuminuria in patients with type - 2 diabetes mellitus was higher than that in healthy cases of the control group (P < 0. 01) and increased as the progress of the disease. The urine IgG, transferrin and α1 - microglobulin were also raised after 10 years of the illness (P < 0. 01 ). The increase of urine microalbuminuria in patients with type - 2 diabetes mellitus and hypertension was higher (P < 0. 01). Conclusion Urine microalbuminuria was a sensitive measurement for the early diagnosis of diabetic nephropathy in patients with type - 2 diabetes mellitus.
出处
《浙江临床医学》
2000年第6期369-370,共2页
Zhejiang Clinical Medical Journal
