摘要
目的探讨不同浓度自体骨髓移植治疗骨不连的实验研究,为临床自体骨髓移植治疗骨不连提供可靠依据。方法选用健康新西兰白兔36只,制作骨不连模型,将所有实验动物随机分为3组:A组:1∶1骨髓组;B组:1∶2骨髓组;C组:1∶4骨髓组。定期进行X线摄片、骨密度测定及组织学观察等,评价骨折愈合情况及骨痂质量。结果术后2、4、8周X线摄片、骨密度测定及组织学观察等各项指标A、B、C组依次增高。结论自体骨髓移植可以提高骨折愈合速度及质量。骨折愈合的速度及质量与移植骨髓的浓度成正比。
Objective To investigate the therapeutic effect of different concentrations of autologous bone marrow transplantation on bone nonunion so as to provide reliable basis for treating bone nonunion in clinic. Methods 36 healthy New Zealand rabbits were selected to make bone nonunion models. All the experimental animals were randomly divided into 3 groups ： group A with 1 ： 1 marrow; group B with 1 ： 2 marrow; group C with 1 ： 4 marrow. The healing state of bone fracture and callus quality were evaluated by regular X-ray examination, bone densitometry and histological observation. Results At 2,4,8 weeks after the operation,the healing state of bone fracture and callus quality were improved in group A, B, C in turn. Conclusion Autologous bone marrow transplantation can enhance healing speed and quality of bone fracture. Healing speed and quality of bone fracture are positively correlated with transplanted bone marrow concentration.
出处
《河北医药》
CAS
2013年第11期1617-1619,共3页
Hebei Medical Journal
关键词
骨不连
骨髓移植
浓度
实验研究
bone nonunion
bone marrow transplant
density
experimental study
