摘要
DNA双键断裂(DNA doubled-strand breaks,DSBs)是目前已知DNA损伤中最为严重的一种,会造成遗传信息丢失,甚至细胞死亡。为了应对DSB损伤,生命体进化出DNA损伤应答(DNA-damage response,DDR)机制,进行损伤修复以防止错误遗传信息的传递。在这一过程中,作为染色质主要结构蛋白的组蛋白发生多种修饰,包括磷酸化、甲基化、乙酰化、泛素化等。这些组蛋白修饰促进DDR相关蛋白在DNA损伤处的招募,并改变染色质结构,以促进修复过程顺利进行。
DNA doubled-strand breaks （DSBs） which is the most serious species in DNA damage can lead to the loss of genetic message or even cell death. To resist DSB damage, the organism has developed a DNAdamage response （DDR） mechanism for DNA damage repair to avoid the transfer of inaccurate genetic message. In this process, histone which is the main structural protein of chromatin is regulated by multi-modifications, such as phosphorylation, methylation, acetylation, ubiquitination and so on. These modifications of histones promote the recruitment of DDR-related protein to the site of DNA damage in the process of DNA damage repair, and change chromatin structure to facilitate repair progress in DDR.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第6期863-869,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31271500)资助的课题~~
