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GATA-1调控红细胞分化的作用及其分子机制 被引量：5

Regulation and Molecular Mechanism of Transcription Factor GATA-1 during Erythroid Differentiation
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摘要 GATA-1是重要的转录调控因子,主要功能是上调红细胞系统相关基因的转录,同时抑制与细胞增殖分裂等相关基因的表达,在红细胞分化过程中发挥着重要作用。GATA-1在红细胞分化中的作用主要是通过对β-珠蛋白基因的调控来实现的。这一作用涉及到了多种辅助因子,这些因子在不同发育时期以多种形式参与β-珠蛋白基因的转录调控。 GATA-1 is a critical transcription factor which is essential for erythroid differentiation. GATA- 1 induces erythroid differentiation through both activation and repression, of erythroid related and proliferation related genes expression. Different transcription factors and cofactors are recruited by GATA-1 to perform the dual functions of regulation. A specific example is that protein-protein interactions between GATA-1 and cofactors are involved in regulation on β-globin gene： they activate transcription by binding at specific cis-regulatory elements at specific stage. In this review, we focus on multiple cofactors cooperating with GATA-1 at different period to activate or repress specific genes which would promote erythroid differentiation.
作者 李艳明 方向东
机构地区 中国科学院大学 中国科学院北京基因组研究所基因组科学与信息重点实验室
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2013年第6期760-767,共8页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:30971673) 国家重大科学仪器设备开发专项子课题(批准号:2011YQ03013404)资助的课题~~
关键词 GATA-1 转录调控 红系分化 β-珠蛋白基因座 GATA-1 transcriptional regulation erythroid differentiation β-globin gene locus
分类号 Q26 [生物学—细胞生物学]
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参考文献46

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同被引文献31

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引证文献5

二级引证文献23

中国细胞生物学学报
2013年 第6期

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