摘要
GFR的标准化对非肿瘤患者，特别是肾供体较为重要。目前研究较多的GFR标准化参数有：体表面积（BSA）、细胞外液容积（ECV）和瘦体质量（LBM）。BSA的准确测定较为困难，且儿童和肥胖者的标准化效能较差；ECV特别适用于健康儿童的标准化，但肾功能受损患者的临床应用价值明显减低；LBM兼具定量准确、适用范围广等优点，现有研究表明其比BSA和ECV更适用于GFR的标准化，但其影响因素尚待进一步深入研究。
Normalizing GFR with variables is important for non-cancer patients, especially for kidney donors. The most frequently evaluated variables are body surface area （BSA） , extracellular fluid volume （ECV） and lean body mass （LBM）. It is difficult to accurately quantify BSA and the power of BSA normalization decreases in children and obesity population. The ECV normalization is suitable for healthy children, but its clinical value decreases in patients with damaged renal function. The LBM can be accurately measured and has a larger serviceable range in the normalization. Ahhough the influence factors of LBM should be extensively evaluated, the available data indicate that LBM is more suitable in the normalization of GFR than BSA and ECV.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2013年第3期238-240,共3页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
安徽省自然科学基金（090413132）
关键词
肾小球滤过率
放射性核素显像
体表面积
体液
体重
Glomerular fihration rate
Radionuclide imaging
Body surface area
Body fluids
Body weight
