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GPR17在中枢神经系统损伤修复中的作用研究进展 被引量：1

Role of G protein-coupled receptor 17 in central nervous system injury
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摘要 G-蛋白偶联受体17(G-protein-coupled receptor 17,GPR17)原是一种孤儿受体,曾被鉴定为新型尿嘧啶核苷酸/半胱氨酰白三烯受体;2011年国际药理学联合会认为,将GPR17归类于白三烯受体条件尚不成熟。GPR17参与多种病理生理过程,如脑损伤、脊髓损伤、少突胶质细胞发育及成熟,这提示GPR17可能成为相关疾病新的治疗靶点。文中就GPR17的配体和拮抗剂、GPR17和其他受体的相互作用及GPR17在中枢神经系统损伤修复中的作用等研究进展进行综述。 G-protein-coupled receptor 17（GPR17）,an originally orphan receptor,was identified as a new uracil nucleotides/cysteinyl leukotriene receptor.However,whether GPR17 is really classified as a leukotriene receptor is a matter deserving further investigation.GPR17 is involved in many physiological and pathological processes including brain injury,spinal cord injury,and oligodendrocyte differentiation.GPR17 may become a new therapeutic target in these diseases.In this article,the research progress on the pharmacology and pathophysiological roles of GPR17 is reviewed.
作者 张壮 魏尔清 卢韵碧
机构地区 卫生部医学神经生物学重点实验室浙江大学医学院药理学系
出处 《浙江大学学报（医学版）》 CAS CSCD 北大核心 2013年第3期355-359,共5页 Journal of Zhejiang University(Medical Sciences)
基金 国家自然科学基金(81173041 81273491) 浙江省钱江人才计划项目(2010R10055) 中央高校基本科研业务费专项资金(2011QNA7015)资助
关键词 中枢神经系统 损伤 受体 G-蛋白偶联 白三烯类 受体 白三烯 半胱氨酸 尿嘧啶核苷酸类 Central nervous system/injuries Receptors G-protein-coupled Leukotrienes Receptors leukotriene Cysteine Uracil nucleotides
分类号 R363 [医药卫生—病理学]
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参考文献19

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浙江大学学报（医学版）
2013年 第3期

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