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川芎嗪注射液辅助治疗糖尿病肾病临床观察 被引量:3

Observation of Chuanxiongqin Injection in Adjuvant Therapy of Diabetic Nephropathy
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摘要 目的观察川芎嗪注射液辅助治疗糖尿病肾病(DN)的临床疗效。方法 78例DN患者随机分为对照组35例,治疗组43例,均予常规治疗,治疗组加用川芎嗪注射液200~400 mg加入0.9%氯化钠注射液静滴,治疗4周后,观察并比较两组疗效及治疗前后血糖、血液流变学、尿蛋白、肾功能变化等情况。结果治疗组总有效率明显高于对照组,且患者尿白蛋白/肌酐比率、空腹血糖、糖化血红蛋白明显低于对照组。结论采用川芎嗪注射液辅助治疗DN疗效较好,能够有效保护和改善肾功能。 Objective: To observe the effect of Chuanxiongqin Injection in adjuvant therapy of diabetic nephropathy.Methods: 78 cases were divided randomly into the control group with the routine therapis and the treatment group with routine therapies plus the Chuanxiongqin Injection.After 4 weeks,some indices were detected and compared between 2 groups such as the blood glucose,the hemorheology and the urine protein.Results: The total effective rate of the treatment group was higher remarkably than that of the contrl group.These indicators of the treatement group were lower than those in the control group significantly including urinary albumin/creatinine,the fasting blood glucose and the glycosylated hemoglobin.Conclusion: It is effectvie that the Chuanxiongqin Injection is used in adjuvant therapy of diabetic nephropathy.It can protect and improve the renal function.
出处 《中国中医急症》 2013年第6期976-977,共2页 Journal of Emergency in Traditional Chinese Medicine
基金 浙江省瑞安市科技局科研课题(201204008)
关键词 川芎嗪注射液 糖尿病肾病 Chuanxiongqin Injection Diabetic nephropathy
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参考文献4

  • 1Ceriello A. New insights on oxidative stress and diabetic com-plications may lead to causal antioxidant therapy [J]. DiabetesCare,2003,26(5) : 1589-1596.
  • 2王吉耀.内科学[M].北京:人民卫生出版社,2006:575—580.
  • 3中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.115-119.
  • 4史大卓.川芎嗪的药理作用诌议[J].中国中西医结合杂志,2003,23(5):377-378. 被引量:58

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