摘要
报道了一个基于脉冲光声技术的测定血糖含量的新方法 .实验结果表明 :即使在有蛋白、盐份、胆固醇等其它血液成份存在的情况下 ,光声技术仍能测定出葡萄糖浓度 .在 170 0nm波长处的测量误差为 18mg/L ,而采用常规的光学方法所能得到的最好结果为 73mg/L .尽管葡萄糖在近红外区域的光吸收较弱 ,但高灵敏度的脉冲光声法仍成功地测定出生理范围内的葡萄糖浓度 ( 30～ 60 0mg/L) .
Recently there is great interest in applying infrared optical spectroscopic technique for blood glucose monitoring. The development of a noninvasive optical monitoring technique for diabetes has important medical implications for the treatment of diabetic patients, whose bodies cannot maintain their normal levels of glucose present in the blood stream. Various optical spectroscopic techniques such as attenuation total reflection, transmission/diffuse reflection spectroscopy, optical polarimetry and Raman scattering have been studied to determine glucose concentrations. These optical techniques are satisfactory for determining glucose concentration in vitro, but suffer from light scattering when applied in vivo. In this paper we report a new method for non invasive glucose monitoring based on pulsed photoacoustic technique. The photoacoustic technique is quite different from optical method in that it does not rely on the direct detection of the reflected, scattered or transmitted light. Therefore light scattering effect due to tissue cells is eliminated. In the experiment, glucose solutions in the concentration range of 30～600?mg/L are used as samples. It is shown that 3 parameters, i.e., optical absorption coefficient, sound velocity and thermal property, of glucose solution, can be determined in a single experiment. The experimental results have shown that the measured photoacoustic signal is proportional to the glucose concentration with a constant slope even in the presence of various blood analytes such as albumin, salt and cholesterol. The accuracy of the measurement at 1?700?nm reaches 18 mg/L, one of the highest ever reported for non invasive glucose concentration measurement.
出处
《南京大学学报（自然科学版）》
CAS
CSCD
2000年第5期632-635,共4页
Journal of Nanjing University（Natural Science）
