摘要
目的探讨法舒地尔对急性有机磷农药中毒迟发性周围神经病变的疗效。方法采用前瞻性随机对照研究方法,对我院2009年2月至2011年12月收治的36例重度有机磷农药中毒患者,随机分为对照组(n=16)和治疗组(n=20),两组均给予阿托品、氯解磷定及血液灌流等常规治疗,治疗组在此基础上给予法舒地尔静脉滴注,对两组患者的临床症状、迟发性周围神经病变的发病率进行分析,观察两组患者临床症状及神经电生理变化,判断其疗效。结果法舒地尔治疗组患者迟发性神经病变发生率明显低于对照组(P<0.05);法舒地尔能显著改善神经传导速度。结论法舒地尔治疗急性有机磷农药中毒能降低迟发性周围神经病变的发病率。
Objective To investigate the therapeutic effect of fasudil on acute organophosphate induced de- layed polyneuropathy （ OPIDP）. Methods The prospective study method was adopted. From February 2009 to Decem- ber 2011,36 severe patients of AOPP were randomly divided into two groups：control group（ n = 16）and fasudil group （ n = 20 ）. The two groups were given combined therapy of atropine, pyraloxime methylchloride and hemoperfusion etc routine treatment, fasudil group was given fasudil. The incidence of OPIDP was estimated. Clinical manifestations and indexs noeurelectrophysiology were measured, clinical therapeutic effect was estimated. Results The incidence of OPIDP was lower in fasudil group（ P 〈 0.05 ） ; Fasudil could improve nerve conduction velocity （ P 〈 0.05 ）. Conclu- sion Fasudil can be applied to treat AOPP,it cart degrade the incidence of OPIDP and cure OPIDP.
出处
《实用药物与临床》
CAS
2013年第5期382-384,共3页
Practical Pharmacy and Clinical Remedies
