摘要
目的:探讨文拉法辛联合心理干预治疗产后抑郁症的临床疗效和安全性。方法:将78例产后抑郁症患者随机分为两组,每组39例,两组均晨口服文拉法辛治疗,研究组在此基础上联合心理干预治疗,观察6周。于治疗前及治疗2、4、6周末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果:治疗后两组汉密顿抑郁量表评分均较治疗前显著下降(P<0.01),同期研究组均较对照组下降更显著(P<0.05或P<0.01);治疗6周末,研究组显效率89.74%、有效率94.87%,对照组分别为69.23%、89.74%;研究组显效率显著高于对照组(x2=3.85,P<0.05),有效率高于对照组,但差异无统计学意义(x2=0.18,P>0.05)。研究组不良反应发生率为33.33%,对照组为35.90%,两组比较差异无统计学意义(P>0.05)。结论:文拉法辛联合心理干预治疗产后抑郁症较单用文拉法辛治疗起效更快,疗效更显著,且安全性高,依从性好。
Objective：To investigate clinical effects and safety of venlafaxine combined with psychological intervention in treatment of postpartum depression. Methods：78 cases with postpartum depression were randomly divided into two groups with 39 cases in each group. All patient orally took venlafaxine in the morning, and the patients in study group received the psychological intervention addi- tionally and were observed for 6 weeks. The clinical efficacy was assessed by Hamilton depression scale （HAMD） and adverse reac- tions were evaluated by rating scale for side effects before the treatment and 2, 4, and 6 weeks after the treatment. Results： After the treatment, the HAMD scores of the two groups both decreased significantly compared with those before the treatment （P 〈0.01 ）, and the decrease of study group was more obvious than that of control group （P 〈0.05 or 0.01 ）. After 6 weeks＇treatment, the significant efficiency and effective rate of study group were 89.74%, and 94.87%, whereas those of control group were 69.23% and 89.74% ; and compared with those of control group, the significant efficiency of study group was significantly higher （ 2 = 3.85,P 〈 0. 05） and the effective rate was higher, but the differences were not statistically significant（x2 = 0.18, P 〉 0.05 ）. The incidence rate of the ad- verse reactions of study group was 33.33%, whereas that of control group was 35.90%, and the difference between the two groups was not statistically significant （P 〉 0.05 ）. Conclusions： Venlafaxine combined with psychological intervention for treating postpartum de- pression has the advantages of faster and obvious curative effects, high safety, and good compliance.
出处
《中国民康医学》
2013年第11期27-29,共3页
Medical Journal of Chinese People’s Health
关键词
产后抑郁症
文拉法辛
心理干预
汉密顿抑郁量表
Postpartum depression
Venlafaxine
Psychological intervention
Hamilton depression scale （HAMD）
