摘要
目的:探讨胰岛素基因的串联重复可变序列(INS-VNTR)与出生大小和婴儿生长发育的相关性。方法:采用队列研究的方法,在孕妇分娩后留取脐带组织或脐血,并随访活产新生儿至12月。使用rs689(-23HphI)的A/T基因分别作为INS-VNTR Ⅰ/Ⅲ基因的标志,应用多元两分类Logistic回归和混合线性模型分别分析INS-VNTR对出生大小及婴儿生长发育的影响。结果:575例胎儿中,Ⅰ/Ⅰ型为524例,占91.13%;Ⅰ/Ⅲ型50例,占8.70%;Ⅲ/Ⅲ型仅1例,占0.17%。含有Ⅲ等位基因的携带者与Ⅰ/Ⅰ基因型相比,出生体重、身长、BMI及巨大儿发生率差异无统计学意义(P>0.05)。在随访到的474名1岁婴儿生长发育资料中,Ⅰ/Ⅰ基因型与Ⅰ/Ⅲ基因型携带者相比,婴儿期的体重、身长、头围、BMI值之Z值差异无统计学意义(P>0.05)。结论:INS-VNTR基因与出生大小及婴儿生长发育之间无相关性(P>0.05),但由于Ⅲ/Ⅲ基因型频率在中国大陆汉人中的低发生率,因而INS-VNTR对中国大陆汉人出生大小及婴儿生长发育的影响还有待将来进一步的研究来充实。
Objective： To explore the correlation between variable number of tandem repeats of insulin gene （INS -VNTR） and birth weight, growth and development of infants. Methods： A cohort study was conducted, umbilical cord tissue samples or umbilical cord blood samples were obtained after delivery, then the cases were followed up until twelve months after delivery, rs689 （-23HphI） A/T gene was used as one sign of INS - VNTR I/Ⅲ gene, multivariate binary logistic regression analysis and mixed linear model were respectively used to analyze the effect of INS - VNTR gene on birth weight, growth and development of infants. Results： Among 575 fetuses, 524 fetuses were found with I / I genotype, accounting for 91.13% ; 50 fetuses were found with I/Ⅲ genotype, accounting for 8. 70% ; only one fetus was found with Ⅲ/Ⅲ genotype, accounting for 0. 17%. There was no statistically significant difference in birth weight, body height, body mass index （BMI）, and incidence rate of macrosomia between the fetuses with Ⅲ allele and the fetuses with I/I genotype （P 〉 0. 05） . A- mong 474 one - year - old infants followed up, there was no statistically significant difference in birth weight, body height, head circumference, Z value of BMI between the infants with I / I genotype and the infants with I/Ⅲ genotype. Conclusion： There was no correlation between INS -VNTR gene and birth weight, growth and development of infants （P 〉 0. 05 ）, because of the low incidence rate of Ⅲ/Ⅲ genotype frequency in mainland Chinese, the effect of INS - VNTR on birth weight, growth and development of infants born by mainland Chinese needs further studies.
出处
《中国妇幼保健》
CAS
北大核心
2013年第17期2737-2740,共4页
Maternal and Child Health Care of China
基金
国家自然科学基金〔30972474〕
国家自然科学基金〔81273066〕
复旦大学研究生创新基金〔EYF201009〕
达能基金〔DIC2006-01〕
高等学校博士学科专项科研基金〔20070246145〕
上海市公共卫生重点学科建设计划〔12GWZX0301〕
