摘要
目的:探讨参七白及汤配合西药治疗急性脑卒中后应激性溃疡(SU)的临床疗效。方法:104例SU患者随机分为观察组和对照组各52例。对照组给予奥美拉唑20 mg,静脉推注,2次/d;西咪替丁200 mg静脉滴注,1次/6 h。观察组在对照组治疗的基础上加用参七白及汤,1剂/d,胃管给药。两组均用药至大便查潜血阴性。监测胃液潜血和胃液pH;检测血红蛋白,红细胞数,红细胞压积及大便潜血情况;检测血浆内皮素水平(ET-1)和胃泌素水平,记录腹胀、腹泻及胃潴留发生情况。结果:治疗后观察组临床疗效明显优于对照组(P<0.05);观察组治疗后胃液pH值高于对照组,血ET-1及胃泌素水平低于对照组(P<0.01);观察组腹胀,腹泻,胃潴留及大出血的发生率低于对照组(P<0.01);观察组大便潜血转阴时间为(8.2±2.64)d短于对照组的(10.5±2.92)d(P<0.05)。结论:参七白及汤能降低SU患者ET-1和胃泌素水平,升高胃液pH值,促进胃肠功能,减少不良反应发生,提高临床疗效。
Objective： To evaluate the clinical effect of Shenqi Baiji soup（SBS） on the treatment of stress ulcer（SU） after acute cerebral stroke.Method： One hundred and four SU patients were randomly dividing into observation group and control group（n = 52 each）.The control group was injected intravenously with omeprazole 20 mg two times a day： cimetidine 200 mg intravenous dripping,6 h a day.Observation group was additionally given SBS,one dose daily through stomach tube.Two groups were treated with medicine until the occult blood in excrement showed negative result.Gastric juice occult blood and pH value were monitored.Hemoglobin,the count of red blood cell,hematocrit and excrement occult blood were determined.Plasma endothelin level（ET-1）,gastrin level,incidence of abdominal distention,diarrhea and gastric retention were also tested and investigated.Result： The clinical effect of observation group was obviously better than that of the control group（P ＆lt; 0.05） after treatment.Gastric juice pH value of observation group was higher than that of control group.Blood ET-1 and gastrin level were lower than those of control group（P ＆lt; 0.01）.The incidence of abdominal distention,diarrhea,gastric retention and hemorrhoea in observation group was lower than those of control group（P ＆lt; 0.01）;fecal occult blood clearance time（8.2 ± 2.64） d in observation group was shorter than that（10.5 ± 2.92） d of the control group（P ＆lt; 0.05）.Conclusion： SBS can lower SU patients’ ET-1 and gastrin level,increase gastric juice pH value,promote the gastrointestinal function,reduce the incidence of adverse reaction,improve clinical effect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第12期297-299,共3页
Chinese Journal of Experimental Traditional Medical Formulae
