摘要
目的观察氟西汀对急性脑梗死患者不同时期运动功能及认知功能障碍的影响。方法选取发病72h内住院的急性脑梗死患者202例,随机分为治疗组及对照组,治疗组是在住院48h内常规二级预防的基础上加用氟西汀治疗,时间3m。截取住院48h内,即氟西汀治疗前、脑梗死后1w、1m、3m 4个时间点分别对两组患者进行NIHSS及MoCA量表检测及一般情况评定,并进行比较。结果卒中后3m,治疗组无论是NIHSS评分还是MoCA评分与对照组比较具有明显的统计学意义(P<0.001),病后1w、1m NIHSS评分及MoCA评分两组比较无统计学差异(P>0.05)。治疗组入院48h内与卒中后3m比较MaCO评分具有统计学意义(P<0.001)。结论 3m的氟西汀治疗能显著改善脑梗死后患者的运动功能障碍及认知功能障碍。
Objective To explore the effects of fluoxetine on motor functional deficits and cognitive functional deficits at different time points after acute cerebrovascular diseases.Methods This was a 3 months randomized,controlled trial.202 cases were enrolled in our study.They were randomly assigned to receive either conventional therapy or induceing fluoxetine based traditional treatment.Four follow up visits were occurred to test scores of National Institutes of Health Stroke Scale（NIHSS） and Montreal cognitive assessment（MoCA）within the 3 months after stroke to assess difference between two groups.Results At 3 months,scores were obviously decrease in NIHSS tests and were greatly increase in MoCA tests in test group.There was no significant difference between two groups at 7 days and 1 months either on motor functional deficits or cognitive functional deficits.Changes of MoCA scores were significant at 48 hours after admission and in 3 months.Conclusion 3 months fluoxetine usage exhibited obvious effects on improving motor function as well as cognitive function with acute cerebrovascular diseases.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第5期416-418,共3页
Journal of Apoplexy and Nervous Diseases
关键词
氟西汀
运动功能障碍
认知功能障碍
Fluoxetine
Motor functional deficits
Cognitive functional deficits
