摘要
目的探讨加替沙星联合雾化吸入盐酸氨溴索治疗老年急性肺炎的临床效果及其安全性,为其临床治疗提供理论依据。方法对医院2011年9月-2012年9月收治的159例老年急性肺炎患者,根据治疗方法分为观察组80例和对照组79例;观察组采用静脉注射加替沙星联合雾化吸入盐酸氨溴索治疗,对照组采用静脉注射加替沙星治疗,连续治疗7d,观察两组患者治疗前后临床症状、细菌学和不良反应等。结果经过7d治疗总有效率观察组为91.25%、对照组为75.95%,两组总有效率差异有统计学意义(P<0.05);观察组患者治疗前检出87株病原菌,治疗后清除79株,清除率为90.80%;对照组治疗前检出86株病原菌,治疗后清除64株,清除率为74.42%,两组病原菌清除率差异有统计学意义(P<0.05);不良反应发生率观察组为13.75%,对照组为11.39%,两组差异无统计学意义。结论加替沙星联合雾化吸入盐酸氨溴索治疗老年急性肺炎的临床效果较好,药物不良反应患者安全耐受,值得在临床推广。
OBJECTIVE To investigate the clinical effect and safety of gatifloxacin combined with inhalation of ambroxol hydrochloride in treatment of elderly patients with acute pneumonia so as to provide theoretical basis for the clinical treatment. METHODS A total of 159 cases of elderly patients with acute pneumonia, who were treated in the hospital from Sep 2011 to Sep 2012, were enrolled in the study and were divided into the observation group with 80 cases and the control group with 79 cases according to the therapeutic methods. The observation group was treated by using intravenous gatifloxacin combined with atomization inhalation of ambroxol hydrochloride, while the control group was treated by using intravenous gatifloxacin, both groups were continuously treated for seven days, then the adverse reaction, bacteriology, and clinical symptoms of the two groups were observed. RESULTS After the treatment for seven days, the total effective rate was 91. 25% in the observation group, 75.95 % in the control group, the difference in the total effective rate between the two groups was statistically sig- nificant （P〈0.05）. Totally 87 strains of pathogens were isolated, among which 79 strains were eradicated with the bacterial clearance rate of 90.80%, and totally 86 strains of pathogens were isolated before the treatment in the control group, among which 64 strains were eradicated after the treatment with the bacterial clearance rate of 74.42%, the difference in the bacterial clearance rate between the two groups was statistically significant （P〈 0.05） ; the incidence of the adverse reactions was 13. 75% in the observation group, 11.39% in the control group, the difference between the two groups was not statistically significant. CONCLUSION Gatifloxacin combined with inhalation of ambroxol hydrochloride can achieve good clinical effect on the treatment of acute pneumonia in the elderly patients, with the adverse reactions of drug tolerant, it is worthy to be promoted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第12期2980-2982,共3页
Chinese Journal of Nosocomiology
基金
浙江省科技厅"钱江人才计划"(20121210050)
关键词
加替沙星
盐酸氨溴索
急性肺炎
Gatifloxacin
Ambroxol hydrochloride
Acute pneumonia
