摘要
目的探讨慢性肾衰竭合并感染患者血清因子变化规律并分析其对策,为临床治疗提供有益参考。方法按照有无合并感染将慢性肾衰竭患者48例分为感染组和未感染组,每组24例,检测其血清生化指标和相关因子含量,从而分析其变化规律。结果感染组血清生化指标与未感染组近似,差异无统计学意义;感染组丙二醛(MDA)、白介素-6(IL-6)、白介素-8(IL-8)和Lp含量分别为(12.35±3.45)μmol/L、(130.33±13.65)pg/L、(190.62±17.25)pg/L和(34.15±2.45)ng/ml,均明显高于未感染组;感染组一氧化氮(NO)、超氧化物歧化酶(SOD)含量分别为(1.78±0.94)μmol/L和(0.73±0.22)mg/L均明显低于非感染组,差异均有统计学意义(P<0.05);感染组内随病情加重,MDA、IL-6、IL-8和Lp含量均呈增高趋势,而NO和SOD含量均呈下降趋势,差异均有统计学意义(P<0.05)。结论慢性肾衰竭合并感染患者其血清因子呈现规律性变化,这对治疗方案制定有指导意义,且应加强护理以使患者病情趋于平稳。
OBJECTIVE To investigate the change rules of serum cytokines in the chronic renal failure （CRE） patients complicated with infections and analyze the countermeasures so as to guide the clinical treatment. METHODS Totally 48 CRF patients were divided into the infection group and the non-infection group according to the status of infections, with 24 cases in each. The contents of the serum biochemical indicators and cytokines were determined, and the change rules were observed. RESULTS The difference in the serum biochemical indica- tors between the infection group and the non-infection group was not statistically signifieant the concentrations of MDA, IL-6, IL-8, and Lp of the infection group were respectively （12.35±3.45）μmol/L, （130.33±13.65）μmol/ L, （190.62±17.25） pg/L, and （34.15±2.45） ng/ml, significantly higher than the non-infection groups the concentrations of NO and SOD of the infection group were respectively （1.78±0. 94）μmol/L and （0.73± 0.22） mg/L, significantly higher than the non-infection group, the difference was statistically significant （P〈 0.05）. With the increased degree of CRF, the concentrations of MDA, IL-6 , IL-8, and Lp showed increasing tendency, while the concentrations of NO and SOD showed descending tendency, the difference was statistically different （P〈0.05）. CONCLUSION The serum eytokines show regular changes in the CRF patients complication with infections, which has great significance in guiding the treatment. It is necessary to strengthen the nursing so as to make the patients condition stabilized.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第12期2793-2795,共3页
Chinese Journal of Nosocomiology
关键词
慢性.肾衰竭
细胞因子
感染
对策
Chronic renal failure
Cytokines
Infection
Countermeasure
