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胃癌转移相关微小RNA的研究进展 被引量：4

Advance in the Study of MicroRNA in Gastric Cancer Metastasis
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摘要 胃癌是我国最常见的恶性肿瘤之一,复发和转移仍就是胃癌治疗的一大难题。微小RNA(miRNA)是一类内源性非编码小RNA,在转录后水平对基因表达进行负调控。可以作为一类新型的癌基因或抑癌基因参与肿瘤的凋亡,生长,侵袭。研究miRNA对胃癌转移发生发展的作用有助于我们寻找治疗胃癌的新方法。本文就miRNA和胃癌转移关系的研究进展做一综述。 Gastric cancer is the most common malignant tumor in China,recurrence and metastasis are major problems in the treatment of gastric cancer.MicroRNAs（miRNAs） are endogenous,small（18-25nucleotides）,non-coding RNAs that play significant roles in gene expression by targeting 3＇UTR of cellular transcripts,resulting mRNA cleavage or translational inhibition,which can play as a novo oncogenes or tumor suppressor genes involved in apoptosis,growth and invasion of tumor.Studying the effect of miRNA is helpful for researching new treatment method of gastric cancer.This review summarized the recent progress on the research field of microRNA and its association with gastric cancer metastasis.
作者 王遂函 李继坤
机构地区 上海交通大学附属第一人民医院普外科
出处 《现代生物医学进展》 CAS 2013年第15期2972-2974,共3页 Progress in Modern Biomedicine
关键词 微小RNA 胃癌 转移 MicroRNA Gastric cancer Metastasis
分类号 R735.2 [医药卫生—肿瘤]
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同被引文献44

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现代生物医学进展
2013年 第15期

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