摘要
目的:观察和比较不同剂量的阿托伐他汀对急性心肌梗死患者血管内皮功能及动脉粥样斑块稳定性的影响。方法:选择我院收治的急性心肌梗死患者56例,随机分为高剂量和低剂量阿托伐他汀治疗组,每组28例。高剂量组给予阿托伐他汀40 mg/d,低剂量组给予阿托伐他汀20mg/d治疗,检测和比较两组患者治疗前后血管舒张功能(FMD)、淋巴细胞刺激指数(SI)和IFN-γ水平的变化。结果:治疗前,两组患者的FMD、SI、IFN-γ水平比较均无统计学意义(均P>0.05)。治疗后,所有患者的FMD均较治疗前显著升高,差异均有统计学意义(低剂量组:t=1.098,P=0.025;高剂量组:t=2.053,P=0.017),且高剂量组FMD显著高于低剂量组,差异有统计学意义(t=2.451,P=0.017);患者SI、IFN-γ水平均较治疗前降低,差异有统计学意义(均P<0.05)。高剂量组SI、IFN-γ均显著低于低剂量组,差异有统计学意义(SI:t=2.234,P=0.002;IFN-γ:t=4.416,P=0.001)。结论:与低剂量阿托伐他汀相比,高剂量阿托伐他汀对急性心肌梗死患者血管内皮功能及炎性反应的改善作用更明显。
Objective： To observe and compare different doses of atorvastatin on the vascular endothelial function and atherosclerotic plaque stability in patients with acute myocardial infarction.Methods： Fifty-six patients with acute myocardial infarction in our hospital were involved.They were randomly divided into high-dose and low-dose atorvastatin treatment groups with 28 cases in each group.40 mg/d of atorvastatin was given in high dose group while 20 mg/d was given in low dose group.The changes of flow-mediated dilation（FMD）,lymphocyte stimulation index（SI） and level of IFN-λ were measured and compared before and after treatment.Results： FMD,SI and IFN-λ level of the two groups were not statistically significant before treatment（P 0.05）.After treatment,FMD of all patients were significantly higher than those before treatment.The differences were statistically significant（low-dose group： t = 1.098,P = 0.025;high dose group： t = 2.053,P = 0.017）.The FMD of high dose group was significantly higher than that in low dose group.The difference was statistically significant（t = 2.451,P = 0.017）;SI and IFN-λlevels were lower than those before treatment.The differences were statistically significant（all P 0.05）.SI and IFN-λlevels in high-dose group were significantly lower than those in low dose group.The differences were statistically significant（SI： t = 2.234,P = 0.002;IFN-λ： t = 4.416,P = 0.001）.Conclusion： Compared with low dose group,the improvement of the vascular endothelial function and inflammatory response in high dose group are more effective.
出处
《现代生物医学进展》
CAS
2013年第15期2940-2942,2917,共4页
Progress in Modern Biomedicine
关键词
阿托伐他汀
急性心肌梗死
血管内皮功能
动脉斑块稳定性
Atorvastatin
Acute myocardial infarction
Vascular endothelial function
Atherosclerotic plaque instability
