摘要
目的:探讨超分割放射治疗副鼻窦癌的毒副反应及近期疗效。方法:回顾性分析26例接受术后超分割放射治疗的副鼻窦癌患者,与常规分割放疗组患者对照,比较两组近期疗效及毒副反应的差异。结果:超分割治疗组3年局控率明显提高,急性期黏膜反应较重,晚期眼部毒副反应较轻,两组间差异有统计学意义(P<0.05),而3年总生存率两组间差异无统计学意义。结论:超分割放疗能够改善局部控制率,且明显降低放射性视网膜病的发病率,可改善患者的生活质量。
Objective：To evaluate the preliminary results and toxicity of postoperative hyperfraction- ated radiotherapy for malignancies of the paranasal sinuses. Methods. Clinical data of paranasal malignancy patients, treated by hyperfractionated radiotherapy, were reviewed. These patients were then compared with a cohort of paranasal malignancy patients treated by conventional fractionation radiotherapy. The preliminary outcomes and radiation-related sequelae of the two groups were compared. Results： Compared with the conventional fractionation radiotherapy, hyperfractionated radiotherapy significantly improved the 3-year locoregional control rate （P〈0.05）. There was no significant differences in the 3-year overall survival rate between the two groups. The occurrence rates of mucositis were significantly higher in hyperfractionated radiotherapy group. Hyperfractionation was associated with a significantly lower incidence of radiation retinopathy. Conclusion：Hyperfractionated radiotherapy can significantly improves the locoregional control and reduce the incidence rate of radiation retinopathy, improve the quality of life.
出处
《华夏医学》
CAS
2013年第2期289-292,共4页
Acta Medicinae Sinica
基金
广西壮族自治区卫生厅资助课题(Z2008283)
关键词
副鼻窦癌
超分割
放射治疗
毒副反应
paranasal cancer
hyperfractionated
radiotherapy
toxicity
