摘要
目的探讨微生态制剂对于老年急性胰腺炎患者的辅助治疗效果。方法选取急性胰腺炎老年患者144例，根据随机数字表法分为观察组和对照组，各72例。所有患者在进行常规治疗的同时给予肠内营养，观察组在营养液中加入微生态制剂。治疗后比较两组患者外周血中内毒素（ET）、肿癌坏死因子（TNF-α）、白细胞介素（IL-6）和C-反应蛋白（CRP）水平，观察临床指标以及不良反应的发生情况。结果治疗后两组患者各指标与治疗前相比均明显改善。观察组治疗后各指标含量水平分别为ET：（0．14±0．07）EU／ml，IL-6：（44．77±17．82）pg／ml，TNF-a：（0．15±0．05）μg／L和CRP：（108．33±11．84）mg／L，均明显低于对照组（t=14．722、43．824、7．071、5．811，均P〈0．05）。观察组患者症状、体征缓解情况，肛门排气、排便时间，住院时间分别为（25．8±4．8）h，（30．9±6．7）h，（24．9±3．2）h和（6．9±0．4）d，均较对照组短（t=4．747、4．401、10．125、33．443，均P〈0．05）。两组患者死亡发生率和不良反应发生率差异均无统计学意义（X^2=0．15、0．07，均P〉0．05）。结论微生态制剂对老年急性胰腺炎患者可起到安全有效的辅助治疗作用。
Objective To explore the auxiliary efficacy of microbial ecological agents for elderly patients with acute pancreatitis. Methods Totally 144 elderly patients with acute pancreatitis were selected and randomly divided into the observe group and the control group （n= 72, each）. All patients received the regular treatment and enteral nutrition. Microbial ecological agents were added in enteral nutrition in the observe group. The levels of endotoxin （ET）, tumor necrosis factor （TNF-a）, interleukin （IL）-6 and C-reactive protein （CRP）in peripheral blood were determined and compared between the two groups. The clinical index and the occurrence of adverse reactions were observed. Results Compared with pretreatment, the levels of ET, TNF-α, IL-6, CRP were significantly reduced in both two groups after treatment. The levels of ET, IL-6, TNF-a, CRP were lower in the observe group than in the control group [（0.14±0. 07）EU/ml vs. （0.31±0.12）EU/ml, （44.77± 17. 82）pg/ml vs. （63.25±14.26）pg/ml, （0.15±0.05）μg/L vs. （0. 29±0.14）μg/L, （108.33±11. 84）mg/L vs. （135.41±21.45）mg/L, t=14.722, 43. 824, 7. 071, 5. 811, respectively, allP〈 0.05]. The recovery time of symptoms and signs, the anal exsufflation time and hospitalization time were shorter in the observe group than in the control group （（25.8±4.8）h vs. （36.4±6.2）h, （30.9 ±6.7）hrs. （44.4±7.3）h, （24.9±3.2）hrs. （37.6±3.4）h, （6.9±0.4）d vs. （13.1±1.2）d, t= 4. 747, 4. 401, 10. 125, 33. 443, respectively, all P〈0.05%. There were no statistically differences in death rate and the occurrence of adverse reactions between the two groups （Z2 = 0.15, 0.64, both P〈 0.05）. Conclusions Microbial ecological agents are safe and effective as an adjuvant therapy for elderly patients with acute pancreatitis. It is worth promoting in clinical medicine.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第6期627-629,共3页
Chinese Journal of Geriatrics
关键词
有益菌种
胰腺炎
Probiotics Pancreatitis
