摘要
目的探讨维持性血液透析患者胰岛素抵抗与颈动脉粥样硬化的相关性。方法将78例非糖尿病肾脏疾病的维持性血液透析患者，根据胰岛素敏感度分为胰岛素抵抗组（A组）和胰岛素敏感组（B组），比较2组颈动脉粥样硬化发生率和各相关因素指标；同时，对颈动脉粥样硬化影响因素进行Logistics回归分析，胰岛素抵抗与颈动脉粥样硬化相关因素进行单因素回归分析。结果A组血脂、血磷、同型半胱氨酸、超敏c反应蛋白（hs—CRP）、白细胞介素6（IL-6）、甲状旁腺素（iPTH）、颈动脉粥样硬化发生率与B组存在明显差异（P〈0．05），对胰岛素敏感性与各危险因素进行Logistic回归分析，发现胰岛素抵抗与高血脂、微炎症相关（P〈0．05）。结论胰岛素抵抗是颈动脉粥样硬化的危险因素，其机制可能与微炎症、脂代谢异常有关。
Objective To explore the relationship between insulin resistance （IR） and carotid artery atherosclerosis （CA） or greater carotid artery intima-media thickness （CIMT） in maintenance hemodialysis patients without diabetes. Methods Seventy-eight maintenance hemodialysis patients were divided into two groups by sensitivity of insulin. Risk factors of CA were compared in the two groups and the relationship between IR and every CA risk factor was analyzed by Logistic regression. Results There was statistically significant difference between the two groups in LDL, TG, total ho- mocysteine, hsCRP, serum phosphorus, IL-6, and CA rate （P^0. 05）. Logistic regression revealed hyperlipemia （LDL and TG） and microinflammtion （hsCRP and IL-6） were related with insulin resist- ance in maintenance hemodialysis patients. Conclusions Insulin resistance was an independent risk fac- tor of greater CIMT or CA.
出处
《临床肾脏病杂志》
2013年第5期225-227,共3页
Journal Of Clinical Nephrology
关键词
血液透析
胰岛素抵抗
颈动脉粥样硬化
颈动脉中膜
微炎症
Hemodialysis
Insulin resistance
Carotid artery atherosclerosis
Carotid artery inti- ma-media thickness
Microinflammation
