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N-亚硝基二甲胺(NDMA)的环境过程和毒理效应 被引量：7

Environment Process and Toxicological Effects of N-Nitrosodimethylamine (NDMA)
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摘要 N-亚硝基二甲胺(NDMA)是一种工业和环境污染物,具有强烈的致癌、致畸和致突变毒性;实验证明它可导致动物很多器官包括肝脏、肺和肾脏的癌症;它几乎无处不在,广泛分布于人类的生活环境中,已引起了人们的高度重视。在综合了大量文献的基础上,充分总结了NDMA的物理和化学性质、来源、毒理学信息和暴露途径等,并就研究中尚未解决的问题作了讨论,以期为NDMA的人类毒理效应研究以及各类标准的制定提供科学依据。 N-nitrosodimethylamine （NDMA）is an industrial and environmental pollutant. It has strong carcinogenic, mutagenic and teratogenic effects. NDMA was demonstrated to cause cancers in organs, including liver, lung, and kidney in animals. It aroused great attention resulting from its wide distribution in the environment. The physical and chemical properties of NDMA, its origins and toxicological data were fully summarized as well as its exposure approach. Additionally, some unsolved problems in this area were discussed. This review aims to provide a theoretical basis for the study of toxic effects of NDMA on human and formulating na- tioal standards of China.
作者 古楠 刘永东 钟儒刚
机构地区 北京工业大学生命科学与生物工程学院
出处 《生态毒理学报》 CAS CSCD 北大核心 2013年第3期338-343,共6页 Asian Journal of Ecotoxicology
基金 国家环保公益项目子课题"环境致癌物N-亚硝胺人体健康水质基准的研究"(2010467032)
关键词 N-亚硝基二甲胺 暴露途径 毒性效应 N-nitrosodimethylamine （NDMA） exposure approach toxicity
分类号 X171.5 [环境科学与工程—环境科学]
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参考文献44

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同被引文献76

  • 1葛雨琦,叶晓霞,乐健,杨永健,王彦.N-亚硝胺类基因毒性杂质毒性与检测方法研究进展[J].药物分析杂志,2020,40(1):83-89. 被引量：53
  • 2李海莹,王薇,金朝晖,张环,宣晓梅,李铁龙.纳米铁的制备及其对污染地下水的脱硝研究[J].南开大学学报（自然科学版）,2006,39(1):8-13. 被引量：31
  • 3Integrated Risk Information System (IRIS),United StatesEnvironmental Protection Agency (EPA),N-Nitrosodimethylamine(CASRN 62-75-9).http://www.epa.gov/iris/subst/0045.htm,2012.
  • 4Najm I,Trussell R R.NDMA Formation in Water and Wastewater[J].American Water Works Association.2001,93(2):92–99.
  • 5Gan J,Bondarenko S,Ernst F,et al.Leaching ofN-nitrosodimethylamine (NDMA) in turfgrass soils duringwastewater irrigation[J].Journal of Environmental Quality,2006,35(1):277– 284.
  • 6Health Canada.N-nitrosodimethylamine (NDMA) in drinkingwater.http://www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/ndma/index-eng.php,2011.
  • 7California Department of Public Health.NDMA and othernitrosamines–drinking water issues.http://www.cdph.ca.gov/certlic/drinkingwater/pages/NDMA.aspx,2013.
  • 8Sakai H,Takamatsu T,Kosaka K,et al.Effects of wavelength andwater quality on photodegradation of N-Nitrosodimethylamine(NDMA)[J].Chemosphere,2010,89(6):702-707.
  • 9Sharp J O,Sales C M,LeBlanc J C,et al.An inducible propanemonooxygenase is responsible for N-nitrosodimethylaminedegradation by Rhodococcus sp.strain RHA1[J].Applied andEnvironmental Microbiology,2007,73(21):6930–6938..
  • 10Sharp J O,Sales C M,Cohen L A.Functional characterization ofpropane-enhanced N-nitrosodimethylamine degradation by twoactinomycetales[J].Biotechnology and Bioengineering.,2010,107:924–932.

引证文献7

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生态毒理学报
2013年 第3期

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