摘要
目的探讨事件相关电位N400在脑卒中后失语症患者康复治疗中的意义。方法选择2010年3月~2012年8月于河北联合大学附属医院住院治疗的脑卒中后失语症患者39为失语组,选择同期脑卒中后无失语症患者78例为对照组;两组分别进行事件相关电位N400的检查,比较两组在潜伏期和波幅方面的差异。结果失语组在Fz、Pz、C3、C4的N400潜伏期[(435.2±51.0)、(426.1±42.8)、(427.9±49.8)、(416.8±47.6)ms]长于对照组[(375.5±32.6)、(375.6±36.9)、(363.9±34.8)、(372.3±35.7)ms],差异均有统计学意义(P<0.05);失语组在Fz、Pz、C3、C4的N400波幅[(3.0±1.9)、(2.8±1.4)、(3.1±1.5)、(2.7±1.3)μV]高于对照组[(1.7±0.8)、(1.9±0.9)、(1.7±0.8)、(1.9±0.9)μV],差异均有统计学意义(P<0.05)。结论 N400对于反映脑卒中后失语症患者语言功能障碍程度有一定的作用,可以在脑卒中后失语症的康复治疗中发挥作用。
Objective To explore the application of event-related potential(ERP) N400 in stroke patients with apha sia.Methods 39 stroke patients with aphasia(aphasia group) and 78 stroke patients without aphasia(control group) from March 2010 to August 2012 in Affiliated Hospital of Hebei United University were selected and examined with N400,and the latency and amplitude of N400 were compared.Results The latency of N400 in Fz,Pz,C3,C4 in aphasia group [(435.2±51.0),(426.1±42.8),(427.9±49.8),(416.8±47.6) ms] were all longer than those in control group [(375.5±32.6),(375.6±36.9),(363.9±34.8),(372.3±35.7) ms],the difference were statistically significant(P &lt; 0.05);the amplitude of N400 in aphasia group [(3.0±1.9),(2.8±1.4),(3.1±1.5),(2.7±1.3) μv] were all higher than those in control group [(1.7±0.8),(1.9±0.9),(1.7±0.8),(1.9±0.9) μV],the difference were statistically significant(P &lt; 0.05).Conclusion N400 is a significant marker for the language disturbance of aphasia patients,which can play a role in the reha bilitation of post-stroke aphasia.
出处
《中国医药导报》
CAS
2013年第17期55-56,59,共3页
China Medical Herald
基金
河北省唐山市科技计划项目(编号12140209A-8)