摘要
目的探讨细胞质胸苷激酶(TK1)在乳腺癌组织中的表达情况,并分析其与Ki-67及临床病理因素间的关系。方法应用免疫组化MaxVison法检测70例乳腺癌组织标本中TK1及Ki-67的表达情况,分析二者与乳腺癌各临床病理学参数间的关系。结果 TK1和Ki-67在70例乳腺癌中的表达与患者年龄、组织学分级、淋巴结转移情况及临床分期相关(分别为χ2=13.40,χ2=12.02,χ2=5.71,χ2=20.26,P﹤0.05),但与肿瘤大小无关,且TK1与Ki-67间呈正相关(r=0.888,P<0.01)。结论 TK1表达在不同级别乳腺癌组织中存在差异,分级高者表达高;TK1同Ki67一样是一个灵敏的反应肿瘤细胞增殖的指标。
Objective To investigate the expression of TK 1 and its correlation of TK 1 with Ki-67 and conventional pathological parameters in breast canccr. Methods TK 1 and Ki-67 expressions in 70 cases of breast cancer were detected by immunohistochemical method. The relationship between expression status of two makers and breast cancer＇s clinic pathological parameters were evaluated. Results Both TK 1 and Ki-67 expression was positively correlated with age, grade, lymph node metastasis and TNM stage, but not with tumor size. There was a significant correlation between the expression ofTK 1 and Ki-67 （r=0.888, P〈0.01）.Conclusion The higher histological grade and TNM stage of tumor are, the higher expressions ofTK 1 and Ki-67 are.TK 1 is a sensitive indicator measuring the proliferation ofthmor cells.
出处
《当代医学》
2013年第16期24-26,共3页
Contemporary Medicine
