摘要
目的研究吴茱萸Euodia rutaecarpa干燥果实的化学成分。方法采用硅胶、Sephadex LH-20等开放柱色谱及半制备HPLC等方法对吴茱萸乙醇提取物进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从吴茱萸95%乙醇提取物中分离得到11个化合物,分别鉴定为吴茱萸碱(evodiamine,1)、吴茱萸次碱(rutaecarpine,2)、3-(2′-羟基乙酰基)-吲哚(3-hydroxyacetylindole,3)、N-反式对羟基肉桂酰基-对羟基苯乙胺[N-(trans-p-coumaroyl)-tyramine,4]、N-顺式对羟基肉桂酰基-对羟基苯乙胺[N-(cis-p-coumaroyl)-tyramine,5]、白鲜碱(dictamnine,6)、吴茱萸春(evolitrine,7)、6-甲氧基白鲜碱(6-methoxydictamnine,8)、茵芋碱(skimmiamine,9)、7-羟基吴茱萸次碱(7-hydroxyrutaecarpine,10)、阿塔宁I(atanine I,11)。结论化合物3为首次从该属植物中分离得到;化合物4～11为首次从该植物中分离得到。
Objective To study the chemical constituents from the fruits of Euodia rutaecarpa.Methods The chemical constituents of ethanol extract from E.rutaecarpa were isolated and purified by chromatography over silica gel,Sephadex LH-20 columns,and semipreparative reversed-phase HPLC.The structures were elucidated on the basis of physicochemical properties and spectral data analyses.Results Eleven compounds were isolated and identified as evodiamine（1）,rutaecarpine（2）,3-hydroxyacetylindole（3）,N-（trans-p-coumaroyl）-tyramine（4）,N-（cis-p-coumaroyl）-tyramine（5）,dictamnine（6）,evolitrine（7）,6-methoxydictamnine（8）,skimmiamine（9）,7-hydroxyrutaecarpine（10）,and atanine I（11）.Conclusion Compound 3 is reported for the first time from the plants of genus Euodia J.R.et G.Forst.and compounds 4—11 are reported for the first time from E.rutaecarpa.
出处
《中草药》
CAS
CSCD
北大核心
2013年第10期1241-1244,共4页
Chinese Traditional and Herbal Drugs
基金
国家"十二五"计划重大新药创新专项(30873385
81274078)
