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儿童川崎病治疗进展 被引量：2

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摘要 川崎病（Kawasaki disease,KD）又称皮肤黏膜淋巴结综合征（mucocutaneous lymfhnode syndrom,MCLS）,是好发于婴幼儿的急性发热性出疹性疾病,以冠状动脉损害为中心的全身性血管炎,其发病机制尚未明确,可能与感染、免疫失调和多种血管活性因子释放相关,此外Uehara等[1]研究发现KD可能存在家族聚集性。冠状动脉损害（coronary artery lesions,CAL）是KD最严重的并发症,可形成冠状动脉扩张或冠状动脉瘤,
作者 米宁
机构地区 白求恩医务士官学校临床医学系
出处 《临床合理用药杂志》 2013年第14期178-180,共3页 Chinese Journal of Clinical Rational Drug Use
关键词 儿童 川崎病 治疗
分类号 R725.4 [医药卫生—儿科]
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参考文献11

  • 1Uehara R, Yashiro M, Nakamura Y, et al. Kawasaki disease in parents and children[J]. Pediatr Infec Dis J,2005,24(5) :429 -433.
  • 2Shrestha S, Wiener H, Shendre A, et al. Role of activating FcR gene polymorphisms in Kawasaki disease susceptibility and intravenous immu- noglobulin response[ J]. Circ Cardiovasc Genet,2012,5 (3) :309 - 316.
  • 3Berard R,Whittemore B, Scueeimarri R. Hemolytic anemia following in- travenous immunoglabulin therapy in patients treated for Kawasaki dis- ease:a report of 4 cases[J]. Pediatr Rheumatol Online J,2012,10( 1 ) : 10.
  • 4Chen C J, Huang FC, Tiao MM, et al. Sonographic gallbladder abnormality is associated with intravenous immunoglobulin resistance in Kawasaki disease[ J]. Scientific World Journal,2012,48:5758.
  • 5Muta H, Ishii M, Egami K, et 81. Early intravenous gamma-globulin treat- ment for Kawasaki diseasethe nationwide surveys in Japan[ J]. J Pediatr,2004,144(4) :496 -499.
  • 6Inoue Y, Kobayashi T, Morikawa A. Treatment of Kawasaki disease [ J ]. N Engl J Med ,2007 ,356 (26) :2746 - 2747.
  • 7Newburger JW. Adding predniselone to standard immunoglobulin therapy is beneficial for patients with severe Kawasaki disease [ J ]. J Pediatr, 2012,161 (5) :967.
  • 8Williams RV, Wiike M, Tani LY, et al. Does Abeiximab enhance re- gression of coronary aneurysms resulting from Kawasaki disease [ J ]. J Pediat rics,2002,109 (1) :41.
  • 9Imagawa T, Mori M, Miyamae T, et al. Plasma exchange for ref ractory Kawasaki disease [J]. Eur J Pediatr,2004,163:263 -264.
  • 10Newburger JW, Taubert KA, Shulman ST, et al. Summary and abrstracts of the seventh international Kawasaki disease symposium: December 4 - 7,2001, Hakone,Japan [ J]. Pediatr Res ,2003,53 ( 1 ) : 153 - 157.

同被引文献20

  • 1于宪一.川崎病治疗的现状和展望[J].实用儿科临床杂志,2004,19(11):922-924. 被引量：42
  • 2卫生部合理用药专家委员会.中国医师药师临床用药指南[M].1版.重庆:重庆出版集团重庆出版社,2009:670.
  • 3翟娟.川崎病的病因及治疗的研究进展[J].中外健康文摘,2013,(31):277-278.
  • 4Nakamura Y, Rashiro M, Uehara R, et al. Epidemiologic features of Kawasaki disease in Japan:results of the 2009 -2010 Nationwide sur - vey [ J ]. Epidemio1,2012,22 ( 3 ) : 216 - 221.
  • 5Onouchi Y, Suzuki Y, Suzuki H, et al. ITPKC and CASP3 polymor- phisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease[J]. Pharmacogenomics, 2013,13 (1) : 52 - 59.
  • 6Kobayashi T, Inoue Y, Otani T, et al. Risk stratification in the de- cision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease [ J ]. Pediatr Infect Dis 2009,28 (6) :498 -502.
  • 7Salguero JS, Duran DG, Peracaula CS, et al. Refractory Kawasaki disease with coronary aneurysms treated with infliximab[ J]. An Ped- iatr(Barc) ,2010,73 (5) :268 - 271.
  • 8Blankier S, McCrindle BW, Ito S,et al. The role of atorvastatin in regulating the immune response leading to vascular damage in a mod- el of Kawasaki disease [ J ]. Clin Exp Immuno1,2011,164 (2) : 193 - 201.
  • 9Hokosaki T, Mori M, Nishizawa T, et al. Long - term efficacy of plasma exchange treatment for refractory Kawasaki disease[ J ]. Pedi- atr Int,2012,54( 1 ) :99 - 103.
  • 10张园海,何跃娥,项如莲,吴蓉洲,徐强,荣星,陈其.川崎病急性期血清对血管内皮MMP-2、MMP-9和TNF-α分泌的影响及IVIG的干预机制探讨[J].中国临床药理学与治疗学,2009,14(5):586-590. 被引量：11

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临床合理用药杂志
2013年 第14期

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