摘要
目的应用HPLC测定盐酸利托君片的有关物质。方法采用Apollo C8色谱柱(250 mm×4.6 mm,5μm),甲醇-磷酸氢二铵和庚烷磺酸钠混合溶液(30∶70)为流动相,流速1.0 mL.min-1,检测波长214 nm。结果盐酸利托君与有关物质分离完全,最低检测限为3×10-5μg,RSD=0.52%。结论方法简便、准确、灵敏,可用于盐酸利托君片有关物质的测定。
OBJECTIVE To determine the related substances of Ritodrine hydrochloride tablets by HPLC.METHOD The separation was performed on Apollo C8 column（250 mm×4.6 mm,5 μm）.The mobile phase consisted of methanol-mixture of diammonium hydrogen phosphate and heptane mahogany acid sodium（30：70）,and the flow rate was set at 1.0 mL·min^-1 with detection wave at 214 nm.RESULTS Under the established chromatographic condition,the related substances and Ritodrine hydrochloride were separated completely,the limit of detection was 3×10-5 μg.The precision was good（RSD=0.52%）.CONCLUSION The method is simple,accurate,specific and sensitive for the determination of Ritodrine hydrochloride tablets and its related substance.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2013年第3期315-316,共2页
West China Journal of Pharmaceutical Sciences
