摘要
本文简要介绍了利用突变型小鼠研究学习和记忆的最新进展。提出了行为模型的选择对研究学习和记忆的重要性。在发育的不同时期研究突变型小鼠的行为 ,将为我们提供有关在发育过程中基因与行为相关性的信息 。
Recent progress in study on learning and memory of mutant mice was summarized in this paper.In our work the conditioned avoidance training of Fyn deficient mice was carried out in a one way avoidance box.In order to avoid eliciting the hyperreactivity to the aversive stimulus,the minimal intensity of electric shock for driving the mouse to run to the safe compartment.The homozygous mutant mice needed much more numbers of trials (79 13±30 1) for reaching the learning criterion than heterozygous (27 38±7 86) and wild type (34 87±10 9) mice did.These results showed that Fyn deficiency impairs associative learning.It was supposed that to select the proper behavioral models seems very important for studying on learning and memory of mutant mice.The behavioral model of conditioned avoidance task may be useful for behavioral study of mutant mice.Moreover,as the gene expression may be different in defferent stages of development,to study the behavioral changes of transgenic mice in different stage of development will provide us more information about the functions of genes.The preliminary results of our recent study on behavior of GABA transported gene ( GAT 1 ) transgenic mice showed that in adult mice GAT 1 was expressed much more than that in young animals.
基金
国家自然科学基金委资助!重点项目 ( 3 96 3 0 14 0 )
