摘要
目的 观察硫氮卓酮的抗癫痫作用。方法 采用皮层应用马桑内酯的方法致痫大鼠。电刺激一侧坐骨神经 ,引导对侧皮层感觉区诱发电位 ,观察海马CA1 CA2 区注射硫氮卓酮对致痫大鼠皮层脑电图和诱发电位的影响。结果 在皮层脑电图出现高频痫样放电期间 ,皮层诱发电位振幅高达 (1.8± 0 .7)mV ,海马内微量注射硫氮卓酮能明显抑制动物皮层脑电图痫样波频率、振幅和皮层诱发电位的振幅。结论 硫氮卓酮的上述作用与减少马桑内酯致痫时Ca2 +流人神经元内有关。
Objective To explore antiepileptic effect of diltiazem.Methods In the experiments, coriaria lactone (CL) was applied to cerebral cortex for making the epilepsy in rats. The electrocoticogram(ECoG)and evoked potential(EP) in cerebral cortex sensory area were recorded on the other site by electrical stimulation of sciatia nerves. The ECoG and EP were observed after the microinjection of diltiazem into CA 1-CA 2 area in epileptic rats. Results The EP was as high as ( 1.8 ± 0.7 ) mV during epileptiform discharges. The intrahippocampal injection of diltiazem markedly inhibited the frequency and amplitude of epileptiform discharges in ECoG and amplitude of EP. Conclusion The inhibitory effect of diltiazem might be related to restraining the Ca 2+ influx into neurons during epileptiform discharges induced by CL.
出处
《中华物理医学与康复杂志》
CSCD
2000年第3期139-141,共3页
Chinese Journal of Physical Medicine and Rehabilitation
基金
国家自然科学基金!资助项目 (39330 2 1 0 )
关键词
癫痫
诱发电位
硫氮卓酮
脑电图
Diltiazem
Epilepsy
Brain mapping
Evoked ptential
