摘要
目的:比较盐酸哌罗匹隆与舒比利治疗首发精神分裂症的临床疗效和安全性。方法:将68例首发精神分裂症患者随机分成治疗组与对照组,各34例。治疗组予盐酸哌罗匹隆治疗,对照组予舒比利治疗,两组治疗均8周。采用阳性与阴性症状量表(PANSS)评定疗效,采用数字划销测验(NCT)评定认知功能,以不良反应量表(TESS)及相关辅助检查评价安全性。结果:治疗组与对照组显效率分别为70.6%,76.5;PANSS阴性症状评分,两组在治疗第4周末开始与治疗前评分差异有统计学意义(P<0.05);NCT测评,治疗第8周末,治疗组与对照组在净分和失误率上比较,差异均具有统计学意义(P<0.01),两组在净分和失误率上分别与治疗前比较,两组净分均较治疗前显著提高,失误率均显著下降,差异均具有统计学意义(P<0.01或P<0.05);治疗组不良反应少。结论:盐酸哌罗匹隆治疗首发精神分裂症阴性症状疗效与舒比利相当,认知功能改善明显,不良反应少,耐受性好。
Objective： Compared with Hydrochloric acid piperazine and sulpiride treatment starting schizophrenia clinical efficacy and safety. Methods ： 68 cases of first episode schizophrenia patients were randomly divided into treatment group and control group, all 34 cases. Treatment group to the piperazine, control group to the sulpiride, treatment in both groups 8 weeks. With the Positive and negative syndrome scale （PANSS） to evaluate the efficacy, the use of the number cancellation test （NCT） to assess cognitive function, Treatment Emergent Symptom Scale （TESS）and secondary inspection to evaluation security. Results： Treatment group and control group significant efficiency was respectively 70. 6%, 76. 5% ;PANSS negative symptom score, the two groups in treatment 4 weeks before treatment, differences in scores was statistically significant （P 〈0. 05） ;NCT evaluation, and treatment of the 8th week, the treatment and control groups in the net points and error rate, the differences were statistically significant （P 〈 0. 01 ）, the two groups on the net points and error rate respectively, compared with before treatment, two group net points than before treatment was significantly im- proved, a significant reduction in error rate, the differences were statistically significant （P 〈 0. 01 or P 〈 0. 05） ; treatment group less adverse reactions. Conclusion： Hydrochloric acid piperazine treatment of the negative symptoms of first episode schizophrenia efficacy and sulpiride, cognitive function improved significantly fewer adverse reactions, and well tolerated.
出处
《中国药物滥用防治杂志》
CAS
2013年第2期89-92,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
盐酸哌罗匹隆
舒比利
首发精神分裂症
阴性症状
认知功能
Hydrochloric Acid Piperazine
Sulpiride
Episode Schizophrenia
Negative Symptoms
Cognitive Function
