摘要
目的探讨经皮椎体成形术(PVP)联合表阿霉素局部化疗治疗脊柱转移瘤的临床疗效。方法选取2009年6月至2011年5月收治的21例脊柱转移肿瘤患者,其中男11例,女10例;年龄53～79岁,平均65.3岁;患者均在C型臂X线机指导下对肿瘤椎体行表阿霉素骨水泥PVP手术,术后观察骨水泥分布及渗漏情况,以疼痛视觉模拟评分(VAS)及Oswesty功能评分评定患者疼痛缓解情况。结果所有患者均顺利完成手术,术中共3例患者发生骨水泥椎旁渗漏,但均未出现脊髓灼伤及双下肢瘫痪等情况。21例患者均获得12个月的短期随访。患者术后疼痛症状均有不同程度改善,术后3d及末次随访时VAS及Oswesty评分均较术前明显降低(P<0.05),术后3d与末次随访时比较差异无统计学意义(P>0.05)。结论 PVP联合表阿霉素局部化疗可迅速减轻患者的局部疼痛症状,维持脊柱稳定性的同时有效杀灭病灶内肿瘤细胞。
Objective To investigate the clinical therapeutic effects of percutaneous vertebroplasty（PVP） combined with pharmorubicin cement in the treatment of spinal metastases.Methods A retrospective analysis was performed in 21 patients（11 males and 10 females,aged 53 ～ 79 years,averaged 65.3 years） who had spinal metastases accepted PVP combined with pharmorubicin cement.The local pain was measured by visual analogue pain scale（VAS） and Oswesty functional scores pre-and postoperatively.Results All patients were been operated successfully,there was no spinal cord and nerves injury happened. Three cases of cement leakage occurred,but no one had any clinical symptoms.The VAS score and Oswesty score had a significant improvement after surgery（P 0.05）.Conclusions PVP combined with pharmorubicin cement is effective in alleviate the local pain which caused by the bone destruction.It can not only kill the tumor cells but also stabilize the vertebrae structure.
出处
《中国肿瘤临床与康复》
2013年第5期530-532,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
经皮椎体成形术
脊柱肿瘤
骨水泥
临床疗效
Percutaneous vertebroplasty Spinal metastases Bone cement Clinical effective
