摘要
对实验组 2种不同类型脑血管畸形〔脑动静脉畸形 (AVMs)及海绵状血管瘤 (CMs)〕标本、对照组正常脑组织血管标本、阳性对照组血管网状细胞瘤标本进行免疫组化染色 ,观察 2种血管生成因子〔血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子 (bFGF)〕在AVMs和CMs中的表达 ,按照血管同一部位着色强度将结果分为 3级。结果发现 :4 4例试验标本中VEGF表达均为阳性 ,VEGF在AVMs与CMs中的表达不同 ,存在显著性差异 (P <0 .0 1 )。VEGF表达与AVMs经否术前栓塞、有无出血无关 ,与CMs有无出血有关 (P <0 .0 5)。提示血管生成因子在所有类型脑血管畸形都有表达 ,血管发生机制可能是广泛弥散激活 ,而与各种血管类型无关。
To subject paraffin processed specimens of 22 cases of arteriovenous malformations (AVMs) and 22 cases of cavernous malformations (CMs) to immunohistochemical staining. Two angiogenic factors were examined, i.e. vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). The results of immunostaining were analyzed by two observes blinded to the antibody and lesion type, and were evaluated in three classes. All 44 lesions were stained positive for VEGF, with the AVMs staining somewhat more intensely ( P <0.01). 13 of 22 AVMs and 17 of 22 CMs demonstrated bFGF with different staining intense ( P <0.01). The staining of VEGF in CMs had difference with lesions hemorrhaged or not ( P <0.05). The results demonstrate that angiogenic growth factors are expressed in all types of cerebral vascular malformations. The pattern of expression suggests diffuse activation of angiogenesis without specific relation to individual vessel types.
出处
《首都医科大学学报》
CAS
2000年第2期140-143,共4页
Journal of Capital Medical University
关键词
血管内皮生长因子
BFGF
脑动静脉畸形
vascular endothelial growth factor
basic fibroblast growth factor
arteriovenous malformations
cavernous malformations
