摘要
目的观察斑蝥酸钠维生素B6注射液联合奈达铂胸腔注入治疗恶性胸腔积液的疗效和不良反应。方法将73例肺癌并发恶性胸腔积液患者随机分为观察组(38例)和对照组(35例),观察组患者用一次性中心静脉引流专用导管胸腔置管闭式引流胸腔积液后,胸腔内注射斑蝥酸钠维生素B6注射液和奈达铂;对照组患者胸腔内仅注射奈达铂。观察组胸腔给药:斑蝥酸钠维生素B6注射液50 ml+生理盐水20 ml+奈达铂100 mg;对照组胸腔给药:奈达铂100 mg+生理盐水70 ml。结果观察组患者的临床总有效率和生活质量改善率均优于对照组(均P<0.05),两组患者不良反应差异无统计学意义(P>0.05)。结论胸腔灌注斑蝥酸钠维生素B6注射液联合奈达铂治疗恶性胸腔积液的疗效优于单用奈达铂,不良反应轻。
Objective To observe the efficacy and adverse reactions of cantharidin sodium vitamin B 6 injection combined with nedaplatin pleural injection for the treatment of malignant pleural effusion. Methods 73 cases of lung cancer complicated by patients with malignant pleural effusions,central venous drainage catheter chest tube closed drainage of pleural effusion,given the intrathoracic drug injection,cantharidin sodium vitamin B 6 injection combined with of nedaplatin（observation group 38 cases）,with nedaplatin only（control group,35 cases）.observation Group pleural administration： the cantharides sodium vitamin B 6 injection 50ml ＋ saline 20ml ＋ nedaplatin 100mg;control group pleural administration： nedaplatin 100mg ＋ saline 70ml.Results Observation group of patients with clinical total rate of efficiency and improved quality of life was better than in control group（P 0.05）,similar to the two sets of adverse reactions.Conclusions Pleural perfusion the sodium cantharidate vitamin B 6 injection in conjunction with nedaplatin treatment of malignant pleural effusion effective than single nedaplatin,and the side effects was mild.
出处
《中国肿瘤临床与康复》
2013年第5期505-507,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
