摘要
目的探讨同期放疗联合化疗与单纯放疗在局部晚期鼻咽癌患者中的疗效。方法将120例局部晚期鼻咽癌患者随机分为观察组和对照组,每组各60例,观察组患者给予同期放化疗治疗,对照组患者给予单纯放射治疗,对比两组患者近期疗效和不良反应情况。结果观察组治疗后原发灶完全消退率为81.7%,颈部转移灶完全消退率为86.7%,均显著高于对照组的61.7%和63.3%(P<0.01)。放疗后3个月时,两组患者原发灶及颈部转移灶完全消退率差异无统计学意义(P>0.05);观察组患者白细胞减少、恶心呕吐等不良反应显著轻于对照组(P<0.05)。结论不是所有局部晚期鼻咽癌患者均适用同期放化疗,在临床具体工作中,仍需密切结合患者临床条件,给予最合理的综合治疗。
Objective To study the clinical effects of concurrent chemoradiotherapy and radiotherapy in patients with locally advanced nasopharyngeal carcinoma（NPC）.Methods 120 patients with locally advanced NPC were randomly divided into the observation group（n = 60） and the control group（n = 60）, the observation group were treated with concurrent chemoradiotherapy,and the control group were treated with radiotherapy,then the recent therapeutical effects and the adverse reaction were contrasted between the two groups.Results Complete extinction rate of the primary lesion in the observation group after therapy was 81.7%,and the cervical metastasis was 86.7%,significantly higher than the control group（61.7% and 63.3%）（P 0.01）;but there was no significantly difference between the two groups 3 months after the therapy（P 0.05）;The condition of leukopenia,nausea and vomiting of the observation group was significantly lighter than the control group（P 0.05）.Conclusions Concurrent chemoradiotherapy is not suitable for all locally adanced NPC patients,we should closely combined with clinical,give the most reasonable comprehensive treatment to patients with locally adanced NPC in clinical work.
出处
《中国肿瘤临床与康复》
2013年第5期461-463,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
放射治疗
化学药物疗法
鼻咽肿瘤
近期疗效
Radiotherapy Chemotherapy Nasopharyngeal neoplasms Recent therapeutical effects
