摘要
目的探讨降钙素原在实体肿瘤化疗后粒细胞减少伴发热患者中的临床应用。方法回顾性分析收治的90例实体瘤伴发热住院患者的临床资料,根据患者的临床症状及体征、病原学和影像学资料,将90例患者分为感染组和发热原因不详组,对比分析两组患者的血清降钙素原水平,以及血清降钙素原水平与患者年龄、性别、发热程度和粒细胞水平之间的关系。结果实体肿瘤化疗后伴发热的患者中,感染组患者血清降钙素原水平明显高于发热原因不详组(P<0.05);血清降钙素原水平在感染组中不同年龄、性别及粒细胞水平间比较,差异均无统计学意义(χ2=1.616、1.099、6.840,P=0.806、0.577、0.145);降钙素原水平在不同发热程度患者间比较,差异无统计学意义(χ2=1.229,P=0.219)。结论在实体瘤化疗后发热的患者中,血清降钙素原水平对于感染的诊断具有重要意义,不受患者的年龄、性别、发热程度和粒细胞水平影响。
Objective To investigate the clinical application of procalcitonin in solid tumors patients with neutropenia associated with fever after chemotherapy.Methods The clinical data of 90 cases of hospitalized patients with solid tumors associated with fever were analyzed retrospectively.90 cases of hospitalized patients were divided into infected group and fever reasons unknown group accorded to clinical symptoms, signs,etiology and imaging.The relationship of serum procalcitonin levels were comparative analyzed between the two groups.The relationship of serum procalcitonin levels with age,gender,heating degree and granulocyte levels were analyzed.Results Serum procalcitonin levels of solid tumors associated with fever patients in the infected group were significantly higher fever reasons unknown group（P 0.05）;Serum procalcitonin levels in different age,gender,and granulocyte levels in the infected group were compared,the difference was not statistically significant（χ2 = 1.616,1.099,6.840,P = 0.806,0.577,0.145）,respectively;The difference of procalcitonin levels in different heating degre was not statistically significant（χ2 = 1.229,P = 0.219）.Conclusions Serum procalcitonin levels has a great significance for diagnosis of infection in solid tumors patients with neutropenia associated with fever after chemotherapy.
出处
《中国肿瘤临床与康复》
2013年第5期452-454,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
降钙素原
发热
粒细胞水平
肿瘤化疗
Procalcitonin Fever Granulocyte levels Cancer chemotherapy
