摘要
为研究尿毒症及血液透析对血清一氧化氮 (NO)浓度的影响及其临床意义 ,应用硝酸盐还原酶法检测了 1 0例尿毒症未透析患者、1 4例维持性血液透析患者透析前后及 1 0例正常对照者血清NO浓度。结果 :尿毒症未透析及血透患者NO水平均较正常对照显著升高 (P <0 .0 5) ,且尿毒症未透析患者血NO浓度与肿瘤坏死因子 α水平呈显著性正相关 (r =0 .858,P <0 .0 0 1 )。血液透析后NO浓度较透析前显著降低 (P <0 .0 5) ,但透析间期又会导致其蓄积。结果提示 :NO的蓄积对尿毒症的临床表现可能有一定影响。
To evaluate the influence of uremia and hemodialysis on nitrogen oxide(NO) product and it′s clincal value, serum levels of nitrogen oxide were measured in 10 uremia undialyzed patients, 14 hemodialysis patients and 10 normal controls. Nitrogen oxide levels were significantly higher in undialyzed patients and hemodialysis patients than normal controls( P <0.05). NO level was correlated with tumor necrosis factor α in ureamia undialyzed patients( r =0.858, P <0.001). Nitrogen oxide decreased considerably ( P <0.05) after hemodialysis but store up again during the interim. The result suggested that enhanced nitrogen oxide product might contribute to some uremic syndromes.
出处
《首都医科大学学报》
CAS
2000年第2期115-117,共3页
Journal of Capital Medical University
