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MAOA-uVNTR多态性与学步期儿童内隐问题行为的关系 被引量：1

Relation between MAOA-uVNTR polymorphism and internalizing problem behaviors of toddlers
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摘要 目的:探究MAOA基因重复片段多态性对学步期儿童内隐问题行为的影响。方法:以295名学步期儿童为研究对象,在儿童6个月时,采集口腔脱落细胞,24个月时由父母报告其内隐问题行为。结果:拥有3型MAOA基因的男孩抑郁、焦虑以及内隐问题行为的水平与4型男孩的水平相比较差异无统计学意义(P>0.05);拥有4/4型MAOA基因的女孩,其抑郁、焦虑以及内隐问题行为的水平与3/3+3/4型女孩差异无统计学意义(P>0.05)。结论:这表明MAOA-uVNTR多态性对学步期儿童抑郁、焦虑以及内隐问题行为均没有显著影响。 Objective： Toddler＇s internalizing problem behaviors is one of the important results of children＇s socialization.It will give rise to the negative effect on children＇s learning,psychological health and personality development.This study aims to investigate the effects of MAOA-uVNTR polymorphism on internalizing problem behaviors of 295 toddlers. Methods： When toddlers aged 6 months,their cheek cells were collected and their internalizing problem behaviors were reported by their parents at the age of 24 months. Results： It was found that boys with 3 genotypes don＇t differ in the level of depression,anxiety and internalizing problem behaviors from that of boys with 4 genotypes significantly.The level of depression,anxiety and internalizing problem behaviors of girls with 3/3 and 3/4 genotypes shows no difference with that of girls with 4/4 genotypes. Conclusion： These results suggest that MAOA-uVNTR polymorphism do not play a role in boy＇s or girl＇s depression,anxiety and internalizing problem behaviors.
作者 汪志鹏 刘亚鹏 张明浩 陈平 张光珍 梁宗保 邓慧华 陆祖宏
机构地区 东南大学学习科学研究中心 东南大学生物科学与医学工程学院 东南大学 鲁东大学心理学院
出处 《东南大学学报（医学版）》 CAS 2013年第3期293-296,共4页 Journal of Southeast University(Medical Science Edition)
基金 教育部科技创新工程重大项目(704025)
关键词 MAOA-uVNTR多态性 学步期儿童 内隐问题行为 抑郁 焦虑 MAOA- uVNTR polymorphism toddler internalizing problem behaviors depression anxiety
分类号 R174 [医药卫生—妇幼卫生保健] R395.2 [医药卫生—医学心理学]
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参考文献14

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共引文献93

同被引文献50

  • 1张洁旭,陈彦博,张克让,许琪,沈岩.单胺氧化酶A启动子可变数目重复序列多态性与中国北方汉族人群重性抑郁症的关联分析[J].中国医学科学院学报,2009,31(6):728-734. 被引量：7
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二级引证文献9

东南大学学报（医学版）
2013年 第3期

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