摘要
目的:探讨血清视黄醇结合蛋白(RBP4)与2型糖尿病(T2DM)视网膜病变发生的相关性。方法:回顾性分析2011年9月至2012年6月间收治的192例T2DM患者(分为合并视网膜病变的DR组和未合并的NDR组)和体检中心59例正常糖调节者(N组)的临床资料和生化指标。结果:N组与NDR组及DR组相比,在年龄、病程、BMI、WHR、SBP、DBP、HbA1c、FBS、FINS、HOMA-IR、T-CH、TG、HDL-C、RBP4、mALB和尿A/C上的差异均有统计学意义(P<0.05),在BFR和LDL-C上差异无统计学意义(P>0.05);NDR组与DR组相比,在年龄、病程、RBP4、mALB和尿A/C上差异有统计学意义(P<0.05)。Logistic多元回归分析显示,年龄、病程、RBP4、mALB、尿A/C、HOMA-IR是T2DM患者发生DR的危险因素,DBP是T2DM患者DR发生的保护性因素。结论:T2DM合并视网膜病变患者的血清RBP4、mALB和A/C水平明显升高。RBP4、HOMA-IR、mALB和A/C是T2DM患者发生DR的危险因素。
Objective： To investigate the association of retinol binding protein 4（RBP4） with type 2 diabetic retinopathy. Methods： Retrospective analysis on clinical parameter and biochemical indicators of 192 cases of type 2 diabetes mellitus and 59 cases of controls in physics examination center from September 2011 to June 2012. Results： Patients with retinopathy（DR group） and without retinopathy（NDR group） were significantly higher in age,duration of diabetic,body mass index,waist hip ratio,systolic blood pressure,diastolic blood pressure,glycosylated hemoglobin A 1 c,fasting blood sugar,fasting insulin,HOMA-IR,total cholesterol,triglyceride,retinol binding protein 4,microalbuminuria and microalbuminuria/creatinine compared with object of controls（N group）（P〈0.05）,and remarkably lower in high-density lipoprotein cholesterol（P〈0.05）;and no statistic difference in body fatter ratio and low-density lipoprotein cholesterol（P〉0.05）.The level of age,duration of diabetic,retinol binding protein 4,microalbuminuria,microalbuminuria/creatinine,HOMA-IR in DR group were significantly higher than those in NDR group（P〈0.05）.Logistic regression analysis showed that age,duration of diabetes,retinol binding protein 4,microalbuminuria/creatinine,HOMA-IR were independent risk factors,and diastolic blood pressure was a protective agent. Conclusion： The level of retinol binding protein 4,microalbuminuria,microalbuminuria/creatinine,HOMA-IR were remarkably increased in type 2 diabetes with retinopathy.retinol binding protein 4,microalbuminuria/creatinine,HOMA-IR in type 2 diabetic patients with retinopathy were independent risk factors.
出处
《东南大学学报（医学版）》
CAS
2013年第3期266-269,共4页
Journal of Southeast University(Medical Science Edition)
基金
黑龙江省政府博士后基金资助项目(LRB07-316)
黑龙江省哈医大二院博士科研基金资助项目(BS2008-33)
