摘要
目的 :研究口服果糖二磷酸钠 (FDP)对动物缺氧及急性脑缺血的保护作用。方法 :采用常压密闭、断头、结扎双侧带迷走神经颈总动脉等方法 ,观察FDP对缺氧及急性脑缺血小鼠死亡时间的影响 ;采用结扎双侧颈总动脉的方法 ,观察FDP对急性脑缺血大鼠的影响。结果 :FDP可明显延长常压密闭、断头、结扎双侧带迷走神经颈总动脉后小鼠的死亡时间 ;可明显降低结扎双侧颈总动脉造成的大鼠脑指数、脑含水量和血清磷酸肌酸激酶的增高 ,对脑血管通透性和血清乳酸脱氢酶的增高有一定的抑制趋势 ,但作用不明显。结论 :口服FDP对动物的缺氧及急性脑缺血有保护作用。
OBJECTIVE:To investigate the therapeutic effects of 1,6 fructose diphosphate(FDP) in mice and rats which were in the induced states of anoxia and acute cerebral ischemia.METHODS:Anoxia was induced in mice with a closed normobaric hypoxia chamber.The clinical condition of acute cerebral ischemia was simulated in mice and rats by decollating and ligating both carotid arteries.FDP was given intragastrically in all tests.RESULTS:Intragastric FDP markedly prolonged the survival time of mice which were in the induced states of anoxia and acute cerebral ischemia. Intragastric FDP markedly decreased the WBR(wet wt of brain/body wt×100) and water weight of brain and inhibited the rise of serum CK in rats with acute cerebral ischemia.Intragastric FDP also improved the capacity of blood passing through the blood vessel. There was a change in serum LDH,but it was not significant.CONCLUSION:FDP has therapeutic effects in mice and rats to counteract the tissue damage caused by the experimentally induced states of anoxia and cerebral ischemia.
出处
《中国现代应用药学》
CAS
CSCD
2000年第3期171-174,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
果糖二磷酸钠
缺氧
急性脑缺血
保护作用
Fructose Diphosphate(FDP),anoxia,cerebral ischemia,protective effects
