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胰岛素制剂的发展 被引量:4

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摘要 1890年Von Meting和Minkowski发现切除狗胰腺可使狗发生糖尿病,从而第一次真正将糖尿病病因和胰腺联系在一起。但1898年Zuelzer及其他学者试图用胰腺提取物治疗糖尿病未获成功,反而引起严重过敏和局部化脓感染。在此后的20余年时间里,大量的实验证据逐步汇集,发现引起糖尿病的病因在于胰腺的内分泌胰岛,胰岛可分泌一种调节血糖稳态的“因子”。
出处 《中华糖尿病杂志》 CAS CSCD 2013年第5期264-267,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
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