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自体骨髓间充质干细胞移植治疗糖尿病:希望与挑战并存

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摘要 在糖尿病的自然病程中,1型糖尿病(T1DM)与2型糖尿病(T2DM)都存在胰岛β细胞的功能衰竭问题,区别仅在于前者β细胞损伤发生在早期,是急进性的,自身免疫过程直接造成其损伤;而后者β细胞功能衰竭则发生在失代偿期,是渐进性的,胰岛素抵抗及慢性低度炎症状态促进了β细胞退行性变。因此,通过各种手段维持或重建胰岛功能一直是糖尿病领域的研究热点。而当前再生医学研究领域的最新进展,无疑为糖尿病的细胞治疗提供更多理论依据和可能性。
出处 《中华糖尿病杂志》 CAS CSCD 2013年第5期260-263,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 国家科技支撑计划(2009BA180804) 中华医学会』临床医学科研专项基金(12030420342) 山东省国际科技合作项目计划(2012GGE27126) 山东省自然科学基金(ZR2012HM014) 2011年山东省医药卫生科技发展计划重点项目(20111-113005)
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