摘要
目的:探讨巨球蛋白血症的临床表现、诊断、鉴别诊断和治疗。方法:分析我科收治的3例巨球蛋白血症患者的临床资料及诊治过程,并复习相关文献。结果:本文3例患者发病时均出现不同程度贫血、单克隆IgM及骨髓浆细胞样淋巴细胞浸润,例1及例3可见高黏滞综合征所致鼻出血或牙龈出血。其中例1及例2接受苯丁酸氮芥联合强的松方案治疗,例3未接受治疗。例1目前病情平稳,例2死亡,例3失访。结论:巨球蛋白血症的诊断与鉴别诊断有赖于形态学及免疫表型检查。烷化剂、嘌呤类似物及利妥昔单抗是WM一线治疗药物。
Objective：To investigate the clinical manifestations,diagnosis,differential diagnosis and therapy of Waldenstrom macroglobulinemia.Methods：We reported three cases of Waldenstrom macroglobulinemia.Its clinical data,diagnosis and treatment were studied and the literatures were reviewd.Results：Anemia,monoclonal IgM protein and bone marrow are infiltrated with lymphoplasmacytic cells were occued on the cases we reported.Nasal bleeding or bleeding gums caused by hyperviscosity syndrome occurred on Ex1 and ex3.Ex1 and ex2 were treated with chlorambucil and prednisone,ex3 refused,ex1 is in stable condition at present,ex2 died,ex3 lost to follow.Conclusion：The diagnosis and differential diagnosis of Waldenstrom macroglobulinemia depends on morphology and immunophenotyping.Alkylating agent,purine and rituximab is its fiest-line therapy.
出处
《现代肿瘤医学》
CAS
2013年第6期1325-1327,共3页
Journal of Modern Oncology
基金
辽宁中医药大学附属医院青年基金资助项目(编号:200906)
