摘要
观察重组γ型干扰素治疗类风湿关节炎 (RA)的疗效。方法 30 3例 RA患者用珠海丽珠生物工程制药厂生产的重组γ型干扰素治疗 ,每周肌注 5天 ,休息 2天 ,每次 1.0 m U,3个月为一个疗程。其中 44例在第 1疗程结束后 ,改为每周肌注 2次 ,每次1.0 m U以巩固疗效 ,共 3个月为第 2疗程。观察治疗前后临床症状、体征 (晨僵时间、关节压痛指数、关节肿胀指数、双手握力 )和实验室检查项目 (血沉、C反应蛋白、类风湿因子、肝、肾功能 )及 X线片 (双手、腕关节 )。结果 治疗 3个月和 6个月总有效率分别为 75 .3%和 88.6 % ,且不良反应轻。结论 重组 γ型干扰素是治疗 RA的一种安全、有效的生物制剂。
Objective To observe the treatment effect of human recombinant interferon on rheumatoid arthritis(RA).Methods 303 cases of RA were injected with human recombinant interferon-γ 1mU for continuously 5 days in one week and the treatment course was 3 months.After the first treatment course,44 of all the cases received injection 1 mIU for 2 days in a week with 3 months as the second treatment course.Observation items included clinical symptoms,body signs and laboratory index such as ESR,RF and CRP as well as the x-ray indications.Results The total curative effects after the treatment for 3 months and for 6 months were 75.3% and 88.6% respectively with minor side effect.Conclusion Human recombinant interferon-γ is a new and effective biochemical medicine for the treatment of rheumatoid arthritis.
出处
《中国综合临床》
2000年第6期430-431,共2页
Clinical Medicine of China
关键词
类风湿性关节炎
药物疗法
重组γ型干扰素
Human recombinant interferon-γ Rheumatoid arthritis Curative effect
