摘要
应用彩色多普勒超声方法 ,对降脂通脉方和洛伐他丁抗动脉硬化进行 2个月观察。结果显示降脂通脉方能够缩小颈动脉斑块面积 ,治疗组颈动脉斑块面积。应用本方治疗AS患者后 ,AS患者总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白 (LDL C)、载脂蛋白 (apo_B)及动脉硬化指数(AI)均降低 ,与对照组作用相似。结果表明降脂通脉方对AS有明确的治疗作用 ,其作用机制可能是通过调节多种脂质成分 。
To evaluate the therapeutic effect of JiangZhiTongMaiFang(JZTMF) on atherosclerosis(AS). 61 patients with AS were taken as treatment group, the patients with lovastating were taken as control. Ultrasonographical technique was used to observe the therapeutic effect of Chinese herbs. In the JZTMF group, the area of plaques was reduced from 0.099±0.051 to 0.0691±0.0273 ( P <0.01, versus baseline); The intima media thickness of common carotid artery were decreased from 0.93±0.19 to 0.79±0.12 ( P <0.01, versus baseline), while there were no distinct changes after treatment of Lovastatin ( P >0.05). JZTMF can adjust the high level of blood lipid in AS patients and the level of plasma TC, TG, LDL ( P <0.001). At the same time, AI (TC_HDL/HDL) and apoB ( P <0.01) clearly went down in JZTMF group. It's proved that JZTMF can treat AS. The main mechanism may be to adjust lipid levels.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2000年第3期52-54,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金! (No.3 95 70 877)
