摘要
目的研究新型的降压药物─血管紧张素受体拮抗剂氯沙坦的降压疗效和对左室肥厚的消退诈用。方法选择高血压左室肥厚患者21例给予氯沙坦口服，治疗前后行24h动态血压监测和心脏彩色多普勒超声检查。结果24h动态血压监测的指标24hSBP、24hDBP、dSBP、dDBP、nSBP、nDBP和心脏超声标志左室肥厚的指标IVST、PWT、LVMI用药后均较用药前有显著下降（P＜0．01）。结论氯沙坦能够明显降低高血压病左室肥厚患者24h血压，并能使其左室肥厚明显消退。
Obijective The study is to assess the Hypotensive effect and the regression of left ventricular hypertrophy by losaran with 24h ambulatory blood pressure monitoring and echocardiography in the patients with Hypertension. Methods 21 hypertensive patients with left ventricular hypertrophy were selected and given losartan treatment alone for 20 weeks. 24 h ambulatory blood pressure monitoring and color doppler echocardiography were performed in the patients before and aftertreatment. Results The parameters (24hSBP、 24HDBP、 dSBP、 dDBP、nSBP、nDBP) of 24 h ambulatory blood pressure monitoring and the parameters (IVST、PWT、 LVMI ) of color doppler echocardiography after treatment in the patients were significantly decreased compared with those before treatment respectively (P<0.01). Conclusion losartan can lower significantly the blood pressure level and make left ventricular hypertrophy remarkable regression in hypertensive patients with left ventricular hypertrophy.
出处
《海南医学》
CAS
2000年第3期10-11,共2页
Hainan Medical Journal
关键词
高血压左室肥厚
药物疗法
氯沙坦
超声心动图
hypertensive left ventricular hyper tensive left ventricular hroertrophy/drug ther losartan use
ambulatory blood pressure monitoring colordoppler echocardiography/methods
