摘要
目的:将CT与MR图像进行融合,比较融合前后勾画的靶区体积,探讨融合技术在放射治疗应用中的价值。方法:收集20例肺癌脑转移患者。增强CT静脉高压注射碘帕醇(30mgI/mL)造影剂,扫描层厚5mm,扫描10.6s;增强MR静脉高压注射Gd-DTPA(0.1mmol/kg体质量)显影剂,行矢状位T1WI和横断位T1WI、T2WI和FLAIR扫描,扫描参数T1WI:TR 440ms,TE 14ms;T2WI:TR 3 200ms,TE 280ms;FLAIR IR:IR 2 000ms;层厚5mm。将CT和MR图像传输至Eclipse工作站并进行CT-MR图像融合,在3种图像上分别勾画GTVCT、GTVMR和GTVCT-MR,比较3种GTV体积,并对比体外标记点法和解剖点法的融合精度。结果:GTVCT、GTVCT-MR和GTVMR体积平均值分别为(25.24±4.73)、(21.8±5.31)和(19.03±3.04)cm3,F=9.709,q=6.21,P=0.001;其中融合组勾画的GTVCT-MR准确度要明显优于CT组GTVCT,q=3.44,P<0.05;融合组GTVCT-MR体积与核磁组GTVMR体积差异无统计学意义,q=2.77,P>0.05。体外标记点法融合精度(1.39±0.64)mm要好于解剖点法(1.97±1.0)mm。结论:CT-MR融合技术能够更准确的确定肺癌脑转移瘤病灶范围;体外标记点法可减少人为误差,融合结果要好于解剖点法。
OBJECTIVE： To detect the accuracy of CT the volome of the GTV contoured on the CT, CT-MR and MR image registration in the radiation therapy by comparing MR. METHODS： The scan time of the enhanced CT with 30 mgI/mL Iopamidol Injection at 5mm slice thickness was 10.6 s. The enhanced MR at 5 mm slice thickness which used 0. 1 mmol/kg Gd-DTPA seaned the T1 WI of the coronal section and the T1WI, T1WI,FLAIR of the transverse section. The parameters of the MR were as follows, T1WI：TR 440 ms,TE 14 ms;T2WI：TR 3 200 ms,TE 280 ms;FLAIR IR：IR 2 000 ms. The images of the 20 patients were transferred to the Eclipse workstation for image fusion. The GTV of each patient was contoured on CT（GTVCT）, CT-MR（GTVCT-MR）, MR（GTVMR）. The volume of GTV on the all sets images and the accuracy of the two image fusion methods in Landmark were contrasted. RESULTS： The mean value of GTVCT, GTVCT-MR and GTVMR were （25.24±4.73） cm3, （21.8±5.31） cm3 , （19.03±3.04） cm3 （F=9. 709,q=6. 21,P= 0.001）. The veracity of the GTVCT-MR was better than that of the GTVCT（q=3.44,P〈0.05）. There was no significant difference between GTVcTMR and GTVMR （q=2. 77, P〉0. 05）. The mean difference of the two kinds of methods were （1.39±0.64） and （1.97± 1.0） mm. CONCLUSIONS： CT-MR image fusion can improve the stability and the accuracy on contouring GTV for lung cancer with brain metastasis. The method with the surface landmark performs better in IMRT.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第12期953-955,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
哈尔滨市科技创新人才研究专项(2010RFQQS066)
