摘要
目的:观察匹多莫德联合川芎嗪治疗小儿支气管哮喘的临床疗效。方法:将我院收治的80例支气管哮喘患儿随机均分成两组。试验组在常规治疗的基础上给予匹多莫德联合川芎嗪联合治疗(匹多莫德分散片,≥10岁,每次800mg,每天2次;<10岁,每次400mg,每天2次,口服;川穹嗪注射液,≥10岁,每次80mg,每天1次;<10岁,每次50mg,每天1次,缓慢静脉滴注;对照组在常规治疗的基础上给予布地奈德气雾剂(吸入,每次100μg,早晚各1次,吸入后漱口)。两组均以7d为1个疗程,连续3个疗程。评定患儿呼气峰流速值(PEF)、血氧饱和度、1s用力呼气容积/用力肺活量(FEV1/FVC)、哮喘起效时间、总有效率和药品不良反应。结果:与对照组比较,治疗后试验组PEF、血氧饱和度、FEV1/FVC、哮喘起效时间和总有效率均显著改善(P<0.05)。治疗组和对照组均出现较轻不良反应。结论:匹多莫德联合川芎嗪治疗中度儿童支气管哮喘有较好的临床疗效。
OBJECTIVE： To observe clinical efficacy of pidotimod combined with ligustrazine in the treatment of children with bronchial asthma. METHODS： 80 children with bronchial asthma in our hospital were randomly divided into 2 groups; 40 patients in trial group were given pidotimod and ligustrazine on the basis of conventional treatment （pidotimod, 〉10 years old, twice a day, 800 mg each time; 〈10 years old, twice a day,400 mg each time,a treatment course lasting for 7 days, receiving 3 treatment courses）; Tetramethylpyrazine hydrochloride and sodium chloride injection, ≥ 10 years old, 80 mg each time;〈 10 years old, 50 mg each time, once a day, slowly drip; a treatment course lasting for 7 days, receiving 3 treatment courses）. 40 patients in control group were given Budesonide aerosol （inhaling, 100 μg each time, morning and night, gargling after inhalation）. Peak expiratory flow（PEF）, ADR, oxygen saturation, FEV1/FVC, onset time of asthma and total effective rate were all evaluated. RESULTS： Compared with control group, the percentage of PEF in predicted value, oxygen saturation, FEV1/FVC, onset time of asthma and total effective rate in trial group were improved significantly（P〈0.05）. Slight ADR were found in two groups. CONCLUSIONS： Pidotimod combined with ligustrazine show sound effect on children with moderate bronchial asthma.
出处
《中国药房》
CAS
CSCD
2013年第23期2189-2191,共3页
China Pharmacy
关键词
匹多莫德
川芎嗪
支气管哮喘
儿童
Pidotimod
Ligustrazine
Bronchial asthma
Children
