摘要
目的:观察芪蓉润肠口服液联合乳果糖治疗高龄老年功能性便秘的临床疗效。方法:将120例高龄老年功能性便秘患者随机分为A、B、C组,每组40例。A组患者口服芪蓉润肠口服液每次20ml,每天3次+乳果糖每次30ml,每天早餐时服用,2d后无明显效果者酌情加量至60ml;B组患者口服芪蓉润肠口服液每次20ml,每天3次;C组患者口服乳果糖每次30ml,每天早餐时服用,2d后无明显效果者酌情加量至60ml。三组疗程均为4周。以患者治疗前后大便频率、性状的改变和排便困难程度为指标评价临床总有效率、总复发率;以生命体征与辅助检查评价药物不良反应。结果:治疗4周后,A、B、C组总有效率分别为97.5%、82.5%和80%,总复发率分别为7.5%、17.5%和20.0%,不良反应发生率分别为2.5%、7.5%和7.5%。结论:芪蓉润肠口服液联合乳果糖治疗高龄老年功能性便秘疗效优于两药单用,并且不良反应较少。
OBJECTIVE： To observe the clinical efficacy of Qirong runchang oral liquid combined with lactulose in the treat-ment of senile functional constipation. METHODS： 120 elderly patients with functional constipation were randomly divided into group A, B, C with 40 cases in each group. The patients in group A received Qirong runchang oral liquid combined with lactulose （oral, Qirong runchang oral liquid 20 ml each time, 3 times a day; lactulose 30 ml, at breakfast, amount added to 60 ml because there was no significant effect 2 days later） ; patients in group B received Qirong runchang oral liquid （oral, 20 ml each time, 3 times a day）; patients in group C received lactulose （oral, 30 ml, at breakfast, amount added to 60 ml because there was no signif-icant effect 2 days later）. Treatment course lasted for 4 weeks. The total clinical effective rate, recurrence rate and adverse drug re-actions were calculated before and after treatment with defecation interval, phenotypic changes, difficult defecation degree, vitals and assistant examination as index. RESULTS： The total effective rates of group A, B, C were 97.5%, 82.5% and 80% after 4 weeks treatment, and the recurrence rate were 7.5%, 17.5% and 20.0%, and the incidence of adverse reaction were 5%, 7.5% and 7.5%, respectively. CONCLUSIONS： The effect of Qirong runchang oral liquid combined with lactulose is better than them alone in the treatment of senile functional constipation with less adverse drug reaction, which can provide reference for clinical use of drugs.
出处
《中国药房》
CAS
CSCD
2013年第23期2184-2186,共3页
China Pharmacy
关键词
芪蓉润肠口服液
乳果糖
功能性便秘
高龄
老年人
疗效
Qirong runchang oral liquid
Lactulose
Functional constipation
Advanced age
Elderly people
Therapeutic effi-cacy
