摘要
[目的]探讨胃食管反流(GER)与慢性咳嗽的关系,以及GER所致的慢性咳嗽———胃食管反流性咳嗽(GERC)的临床特征、诊断和治疗。[方法]50例GERC患者(病例组)和30例健康体检者(对照组)纳入研究,行24h食管pH监测来分析慢性咳嗽与GER的相关性。病例组患者随机分为2亚组,A亚组22例,给予雷尼替丁(150mg,2次/d);B亚组28例,给予奥美拉唑(20mg,2次/d)和莫沙比利(5mg,3次/d)口服;疗程均为8周。比较病例组与对照组24h食管pH监测指标,病例组中A、B亚组疗效和治疗后24h食管pH监测指标变化。[结果]病例组患者Demeester总积分均≥12.7,各项反流指标均显著高于对照组(P<0.05)。病例组患者治疗8周后24h食管pH监测各项反流指标均较治疗前降低(P<0.05),B亚组疗效优于A亚组(z=2.332,P<0.05);且B亚组24h食管pH监测各项反流指标均较A亚组降低(P<0.05)。[结论]GER与慢性咳嗽密切相关,是导致GERC的一个重要原因,对GERC患者应给予抑酸和抗反流治疗。
[Objective]To explore the association between gastroesophageal reflux （GER） and chronic cough,and to investigate the clinical features, diagnosis and treatment of gastroesophageal reflux induced cough （GERC）. [Methods] Fivety GERC patients and 30 healthy cases were enrolled in this study. The correlation of GER and cough were analyzed by 24-hour continuous ambulatory esophageal pH measure- ment. GERC patients were randomly divided into two groups： A group （n=22） was given Ranitidine （150mg,twice per day）, and B group was given Omeprazole （20mg, three times per day）and Mosapride （5mg,three times per day）,and the course of treatment was 8 weeks. The curative effect and the index of continuous ambulatory esophageal pH of two groups were analyzed. [Results]In GERC group, the De- meester score of each patient was ≥12.7, and each index of continuous ambulatory esophageal pH was higher than that in control group. Each index of continuous ambulatory esophageal pH in B group was lower than that in A group post-therapy （P〈0.05）. The recovery rate,effective power and inefficiency in B group was 50% （14/28）,42. 9% （12/28） and 7.1% （2/28）, and those in A group was 36.4% （8/22）, 40. 9%（9/22） and 22.7%（2/22）,and the curative effect of B group was better than A group. [Conclusion] GER is closely associated with cough and may be an important factor inducing chronic cough. The patients with GERC should be treated with acid suppression anti-reflux.
出处
《中国中西医结合消化杂志》
CAS
2013年第5期253-256,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
胃食管反流
咳嗽
相关性
gastroesophageal reflux
cough
relativity
