摘要
目的探讨不同剂量糖皮质激素在急性低频下降型感音神经性聋治疗中的疗效。方法将60例急性低频下降型感音神经性聋患者按糖皮质激素使用剂量分为高剂量组、低剂量组和对照组，每组20例。三组均给予相应的对症支持治疗措施，在此基础上高剂量组患者给予每日1次静脉滴注甲泼尼龙80mg共5d，低剂量组患者给予每日1次静脉滴注甲泼尼龙60mg共5d，对照组患者不给予糖皮质激素治疗。观察三组患者的疗效。结果高剂量组总有效例数明显多于低剂量组和对照组（18例比14例和7例），低剂量组总有效例数亦明显多于对照组，差异均有统计学意义（JP〈0．05）。低剂量组和高剂量组均未出现与使用糖皮质激素有关的明显不良反应。结论急性低频下降型感音神经性聋行高剂量糖皮质激素治疗有更好的疗效，可以明显改善患者的临床症状，值得临床推广应用。
Objective To study curative effect on different dose of glucocorticoid in treatment of acute low-frequency descent type sensorineural deafness. Methods Sixty patients with acute low-frequency descent type sensorineural deafness were divided into high dose group,low dose group and control group according to the dose of glucocorticoid with 20 cases each,all the patients were given corresponding suit support treatment, on the basis of high dose group patients were given every day once intravenous drip methylprednisolone 80 mg for 5 d,low dose group patients were given every day once intravenous drip methylprednisolone 60 mg for 5 d, control group patients did not give glucocorticoid. The curative effect of 3 groups was observed. Results The total effective cases of high dose group was significantly more than that of low dose group and control group （18 cases vs. 14 cases and 7 cases）,and low dose group was significantly more than control group,there were significant differences （P 〈 0.05）. The high dose group and low dose group were no obvious adverse reactions associated with the use of glucocorticoid. Conclusion The patients with acute low-frequency descent type sensorineural deafness treated with high dose glucocorticoid therapy has better curative effect, can significantly improve patients with clinical symptoms, it is worthy of clinical application.
出处
《中国医师进修杂志》
2013年第15期28-30,共3页
Chinese Journal of Postgraduates of Medicine
