摘要
目的观察盐酸氟西汀联合心理干预对慢性心力衰竭(CHF)患者预后的影响。方法选择CHF合并焦虑抑郁障碍患者63例,简单随机分为2组。干预组32例在常规抗心力衰竭药物治疗基础上给予盐酸氟西汀联合心理干预,对照组31例只给予常规抗心力衰竭药物治疗。2组患者均在治疗4周后进行焦虑自评量表(SAS)和抑郁自评量表(SDS)评分,并评估心功能分级(NYHA)、心排量(CO)、左室射血分数(LVEF)、短轴缩短率(FS)。每个月对所有患者进行随访,获取患者再入院率和死亡率,连续随访至初诊后3个月。结果治疗4周后,干预组的SAS、SDS评分均显著低于对照组(P<0.05);LVEF、CO、FS显著高于对照组(P<0.05),NYHA分级明显下降;干预组患者3个月时再入院率和死亡率均明显低于对照组患者(P<0.05)。结论盐酸氟西汀联合心理干预可显著缓解CHF患者的焦虑抑郁情绪,并显著改善患者的预后。
Objective To explore the influence of Fluoxertine hydrochloride combined with psychological in： tervention on the prognosis of chronic congestive heart failure （CHF） patients with anxiety and depression. Methods 63 CHF patients with anxiety and depression disorder were enrolled in the study, and were divided into two groups randomly ： the treatment group and the control group. The treatment group received fluoxertine hydrochloride and psy- chological intervention. The control group received placebo. Self - rating anxiety scale （SAS） and self - rating depres- sion scale （SDS） were distributed to the patients after 4 months treatment. After four weeks, all patients were as- sessed the heart function classification （NYHA）, cardiac output （CO）, left ventricular ejection fraction （LVEF） and short shaft fractional shortening （FS）. All patients were followed up per- month, and obtained rehospitalization rate and mortality of patients within 3 months. Results After 4 months treatment, the SAS, SDS score of the treat- ment group were significantly lower than the control group （P 〈 0.05 ） ; LVEF, CO and FS of the treatment group were significantly higher than the control group （ P 〈 O. 05 - O. 01 ）, and the NYHA classification of the treatment group were decreased obviously; In the 3 months follow - up, the rehospitalization rate and mortality of intervention group was significantly lower than the control group （ P 〈 O. 05 ）. Conclusion Fluoxertine hydrochloride combined with psychological intervention can significantly relief anxiety and depression of CHF patients, and improves the prog- nosis of CHF patients.
出处
《河北中医》
2013年第4期632-634,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
慢性病
心力衰竭
焦虑
抑郁
心理疗法
氟西汀
Chronic congestive heart failure
Anxiety
Depression
Psychological intervention
Fluoxertinehydrochloride
